Randomized Study Comparing Conventional Dose Treatment Using a Combination of Lenalidomide, Bortezomib and Dexamethasone to High-Dose Treatment With ASCT in the Initial Management of Myeloma in Patients up to 65 Years of Age
试验速览
- 阶段
- 3 期
- 状态
- 已完成
- 入组人数
- 700
- 试验地点
- 129
- 主要终点
- Progression Free Survival
研究概览
简要总结
Objective of this study is to determine if, in the era of novel drugs, high dose therapy (HDT) is still necessary in the initial management of multiple myeloma in younger patients. HDT as compared to conventional dose treatment would be considered superior if it significantly prolongs Progression-free survival (by at least 9 months).
详细描述
Study design Phase III, multicenter, randomized, open-label study designed to evaluate the clinical benefit from the drug combination RVD without immediate high-dose therapy (HDT) followed by lenalidomide maintenance (Arm A) versus RVD plus HDT and PBSCT followed by lenalidomide maintenance (Arm B).
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 65 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •for registration :
- •(with labs performed within 21 days of initiation of protocol therapy):
- •Patients diagnosed with multiple myeloma based on International Myeloma Foundation 2003 Diagnostic Criteria.
- •Patients must have symptomatic myeloma with myeloma-related organ damage.
- •Patients must have myeloma that is measurable by either serum or urine evaluation of the monoclonal component or by assay of serum free light chains.
- •Age between 18 and 65 years at the time of signing the informed consent document.
- •ECOG performance status <2 (Karnofsky ≥ 60%)
- •Negative HIV blood test
排除标准
- •for registration (section 4.2):
- •Participants must not have been treated with any prior systemic therapy for multiple myeloma. Treatment by localized radiotherapy is not an exclusion criterion if an interval of at least two weeks between the end of radiotherapy and initiation of protocol therapy entry in the study is observed. Similarly, the dose of corticosteroids received by the participant should not exceed the equivalent of 160 mg of dexamethasone over a two-week period before initiation of protocol therapy.
- •Primary amyloidosis (AL) or myeloma complicated by amylosis.
- •Participants may not be receiving any other study investigational agents.
- •Participants with known brain metastases
- •Poor tolerability or known allergy to any of the study drugs or compounds of similar chemical or biologic composition to study agents
- •Platelet count < 50,000/mm3 per µLwithin 21 days of initiation of protocol therapy. Transfusion within 7 days of screening is not allowed to meet platelet eligibility criteria.
- •ANC < 1,000 cells/mm3 within 21 days of initiation of protocol therapy. Growth factor within 7 days of screening is not allowed to meet ANC eligibility criteria.
- •Hemoglobin < 8.0 g/dL within 21 days of initiation of protocol therapy. Transfusion may be used to meet hemoglobin eligibility criteria.
- •Hepatic impairment, defined a bilirubin > 1.5 x institutional upper limit of normal (ULN) > 2 mg/dL (Patients with benign hyperbilirubinemia (e.g., Gilbert's syndrome) are eligible) and or AST (SGOT), or ALT (SGPT), or alkaline phosphatase > 2 x ULN
- •Renal insufficiency, defined as serum creatinine > 2.5 mg/dl and/or creatinine clearance < <40 60 ml/min (actual or calculated). The Cockgroft-Gault formula should be used for calculating creatinine clearance values, and may be located in Section 4.2
- •Respiratory compromise, defined as ventilation tests and with DLCO < 50%
- •Participant must not demonstrate with clinical signs of heart or coronary failure, or evidence of LVEF < 40%. Participant must not have with myocardial infarction within 6 months prior to enrollment or have New York Heart Association (NYHA Appendix VII) Class III or IV heart failure, uncontrolled angina, severe uncontrolled ventricular arrhythmias, or electrocardiographic evidence of acute ischemia or active conduction system abnormalities. Prior to study entry, any ECG abnormality at screening has to be documented by the investigator as not medically relevant.
- •Intercurrent illness including, but not limited to ongoing or active severe infection, known (active or not) infection with hepatitis B or C virus, poorly controlled diabetes, severe uncontrolled psychiatric disorder or psychiatric illness/social situations that would limit compliance with study requirements.
- •Participant with previous history of another malignant condition, except for basal cell carcinoma and stage I cervical cancer
- •Female participant who is pregnant or breast-feeding
- •Inability to comply with an anti-thrombotic treatment regimen
- •Peripheral neuropathy ≥ Grade 2 peripheral neuropathy on clinical examination within 21 days of initiation of protocol therapy
- •Mental illness likely to interfere with participation in the study and Adults under juridical protection
研究组 & 干预措施
lenalidomide, bortezomib with ASCT
RVD q 21 days (2 cycles) Collection of peripheral blood stem cells (PBSCs) using cyclophosphamide and GCSF (type Granocyte® or equivalent)
Autologous stem cell transplant:
Melphalan: infused over two days (day -2 and day -1) or as a single infusion (day-2) according to institutional practice Re-infusion of PBSCs RVD q 21 days (2 cycles) Maintenance Lenalidomide q28 days (12 months)
干预措施: Lenalidomide, Bortezomib (Drug)
lenalidomide, bortezomib without ASCT
RVD q 21 days (2 cycles) Collection of peripheral blood stem cells (PBSCs) using cyclophosphamide and GCSF (type Granocyte® or equivalent) RVD q 21 days (5 cycles) Maintenance Lenalidomide q28 days (12 months)
干预措施: Lenalidomide, Bortezomib (Drug)
结局指标
主要结局
Progression Free Survival
时间窗: up to 4 years
To compare progression-free survival (PFS) between the Arm A and Arm B up to 4 years or until progression
次要结局
- Genetic prognostic groups definition(up to 4 years)
- Best treatment examination in each GEP-defined prognostic group.(up to 4 years)
- Response Rates(up to 4 years)
- Time To Progression(up to 4 years)
- Toxicity comparison(up to 4 years)