Allergy Risk and Sensitization Following Necrotizing Enterocolitis
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 入组人数
- 130
- 主要终点
- The effect of necrotizing enterocolitis development in premature infants on response to allergens.
研究概览
简要总结
To evaluate the frequency of allergy between 12 and 24 months of age in infants who were treated in the neonatal clinic and had NEC. To investigate the relationship between NEC development and the development of allergy in the later period.
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Crossover
- 主要目的
- Diagnostic
- 盲法
- None
入排标准
- 年龄范围
- 12 Months 至 24 Months（Child）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Infants born in our hospital and diagnosed with NEC during the study period.
- •Age-matched control infants born in our hospital during the same period but without NEC diagnosis.
- •Written and verbal informed consent obtained from at least one parent.
排除标准
- •Infants whose parents did not provide written or verbal consent.
- •Infants with major congenital anomalies.
- •Infants with chromosomal disorders.
- •Infants with gastrointestinal malformations (e.g., duodenal atresia, gastroschisis, omphalocele).
- •Infants diagnosed with immunodeficiency. -
研究组 & 干预措施
NEC Study Group
Neonates diagnosed with Necrotizing enterocolitis during the neonatal period who are eveluated for allergens sensitization
干预措施: skin prick test (Diagnostic Test)
Control Group
Neonates without a history of Necrotizing enterocolitis who are eveluated for allergens sensitization
干预措施: skin prick test (Diagnostic Test)
结局指标
主要结局
The effect of necrotizing enterocolitis development in premature infants on response to allergens.
时间窗: Through study completion, an average of 1 year
The primary objective of this study was to compare the positivity rates on skin prick tests for airway allergens or food allergens in premature infants who developed NEC and those who did not, between the ages of 12 and 24 months.
次要结局
未报告次要终点