Cognitive deficits in brain tumor patients after neurosurgery: incidence, severity and prediction of outcome
- Conditions
- Primary brain tumorgliomameningiomaneurosurgeryobjective cognitive functioningcognitive deficitsneuropsychological impairment<br /><br />Primaire hersentumorgliomenmeningeomenhersenoperatie/neurochirurgie
- Registration Number
- NL-OMON26139
- Lead Sponsor
- St Elisabeth Hospital, TilburgTilburg University
- Brief Summary
Cognitive improvement in meningioma patients after surgery: Clinical relevance of computerized testing. Meskal, I., Gehring, K., van der Linden, S.D., Rutten, G-J.M. & Sitskoorn, M.M. 2015 In: Journal of Neuro-Oncology, 121(3), 617-625
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- Not specified
- Target Recruitment
- 200
Adult patients with supratentorial gliomas and meningiomas undergoing resective surgery in the St. Elisabeth Hospital, Tilburg. Eligible subjects for the control group (recruited from the general population and matched for age, gender and educational level) should be in good health, with no current or past psychiatric, neurologic, or cognitive disorder, and medication-use that interferes with cognitive function.
Patients and Dutch control subjects will be excluded if 1) they lack of basic proficiency in Dutch, 2) they have an IQ below 85 or low cognitive skills, 3) their Karnovsky Performance Scale is under 60, 4) they are completely unfamiliair with the use of computers, 5) they have an additional (history of) significant neurological or psychiatric disorder, 6) there is a surgery related complication (morbidity or mortality).
Study & Design
- Study Type
- Not specified
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Changes in objective cognitive functioning from pre-surgery to post-surgery, as measured with a computerized neuropsychological test battery, CNS Vital Signs.
- Secondary Outcome Measures
Name Time Method Depression, anxiety, subjective cognitive complaints, fatigue, community integration and professional functioning, as measured with the Hospital Anxiety and Depression Scale (HADS), the Cognitive Failures Questionnaire (CFQ), Multidimensional Fatigue Inventory (MFI), Community Integration Questionnaire (CIQ), Work Ability Index (WAI) and Work Limitations Questionnaire (WLQ) respectively.