Correlation Between Aqueous Protein Level and Clinical Grading of Flare and Flaremetry.

Not Applicable

Completed

• Conditions: Uveitis
• Interventions: Procedure: Paracentesis of the anterior chamber

• Registration Number: NCT01905579
• Lead Sponsor: The Eye Center and The Eye Foundation for Research in Ophthalmology

Brief Summary

The purpose of this study is to compare flaremetry readings with the protein content of the aqueous humor and the clinical grading of flare.

Detailed Description

A total of 20 patients will be included. 10 patients with uveitis and 10 control patients scheduled for phacoemulsification. Each patient will undego complete ophthalmic examination and clinical biomicroscopic grading of the anterior chamber flare applying the SUN working group grading system. Aqueous specimens will be obtained by anterior chamber paracentesis for protein analysis. Each Patient will undego paracentesis and 0.2 ml of aqueous will be obtained. The aqueous sample will be stored at -70°C until the time of analysis for protein content. Objective assessment of flare will be done.

Study Timeline

• Study Start: 2013-03
• Primary Completion: 2013-07
• Study First Submitted: 2013-07-18
• Study First Submitted QC: 2013-07-22
• Study First Posted: 2013-07-23
• Study Completion: 2013-08
• Status Verified: 2014-08
• Last Update Submitted: 2014-08-29
• Last Update Posted: 2014-09-01

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 20

Inclusion Criteria

• 10 patients with uveitis with cataract
• 10 patients without uveitis with cataract
• Inactive inflammation for at least 3 months

Exclusion Criteria

• Infectious uveitis
• endophthalmitis
• cases with corneal scar

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
patients without uveitis	Paracentesis of the anterior chamber	Paracentesis of the anterior chamber in patients without uveitis undergoing routine cataract surgery
patients with uveitis	Paracentesis of the anterior chamber	Paracentesis of the anterior chamber in Paients with uveitis undergoing cataract surgery

Primary Outcome Measures

Name	Time	Method
compare flaremetry readings with the protein content of the aqueous humor	one month	Compare flaremetry readings with the protein content of the aqueous and the clinical grading.

Trial Locations

Locations (1)

The Eye Center; 🇸🇦 Riyadh, Saudi Arabia