The Effects of Preoperative Aspirin on Graft Patency and Cardiac Events in Off-pump Coronary Artery Bypass
试验速览
- 阶段
- 3 期
- 发起方
- 入组人数
- 200
- 试验地点
- 1
- 主要终点
- graft patency examined by CT scan
研究概览
简要总结
Antiplatelet therapy is critical in the management of coronary artery disease.For patients undergoing off-pump coronary artery bypass graft,controversy remains regarding the safety of preoperative antiplatelet therapy.And there is little study about the effect of continuing aspirin until the surgery day on graft patency.So we would like to perform this study to evaluate the effects of preoperative aspirin on graft patency and cardiac events in off-pump coronary bypass.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 85 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients undergoing elective, off-pump coronary artery bypass with at least two grafts
- •patient able to give informed consent
排除标准
- •on-pump CABG
- •combined with the valve surgery
- •Preoperative use of clopidogrel and warfarin
- •allergy to aspirin
- •History of severe liver disease
- •History of bleeding diathesis,significant GI bleed
- •Patient has known renal failure or contraindication for Cardiac CT Angio
- •Redo CABG
研究组 & 干预措施
preoperative aspirin use
干预措施: aspirin (Drug)
preoperative aspirin nonuse
干预措施: aspirin (Drug)
结局指标
主要结局
graft patency examined by CT scan
时间窗: one week after surgery
we would like to compare the graft patency within the one week after the surgery between the preoperative aspirin use and preoperative nonuse.We just want to know wether preoperative aspirin use could improve the graft patency in off-pump coronary artery bypass.
次要结局
- Bleeding, transfusion, re-exploration(perioperative)