The Effects of Preoperative Aspirin on Graft Patency and Cardiac Events in Off-pump Coronary Artery Bypass

Phase 3

• Conditions: Coronary Artery Disease; Aspirin; Off-pump Coronary Artery Bypass
• Interventions: Drug: aspirin

• Registration Number: NCT01268917
• Lead Sponsor: Chinese Academy of Medical Sciences, Fuwai Hospital

Brief Summary

Antiplatelet therapy is critical in the management of coronary artery disease.For patients undergoing off-pump coronary artery bypass graft,controversy remains regarding the safety of preoperative antiplatelet therapy.And there is little study about the effect of continuing aspirin until the surgery day on graft patency.So we would like to perform this study to evaluate the effects of preoperative aspirin on graft patency and cardiac events in off-pump coronary bypass.

Detailed Description

Not available

Study Timeline

• Status Verified: 2010-03
• Study Start: 2010-03
• Study First Submitted: 2010-12-29
• Study First Submitted QC: 2010-12-30
• Last Update Submitted: 2010-12-30
• Study First Posted: 2010-12-31
• Last Update Posted: 2010-12-31
• Primary Completion: 2011-03

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 200

Inclusion Criteria

• Patients undergoing elective, off-pump coronary artery bypass with at least two grafts
• patient able to give informed consent

Exclusion Criteria

• on-pump CABG
• combined with the valve surgery
• Preoperative use of clopidogrel and warfarin
• allergy to aspirin
• History of severe liver disease
• History of bleeding diathesis,significant GI bleed
• Patient has known renal failure or contraindication for Cardiac CT Angio
• Redo CABG

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
preoperative aspirin use	aspirin	-
preoperative aspirin nonuse	aspirin	-

Primary Outcome Measures

Name	Time	Method
graft patency examined by CT scan	one week after surgery	we would like to compare the graft patency within the one week after the surgery between the preoperative aspirin use and preoperative nonuse.We just want to know wether preoperative aspirin use could improve the graft patency in off-pump coronary artery bypass.

Secondary Outcome Measures

Name	Time	Method
Bleeding, transfusion, re-exploration	perioperative

Trial Locations

Locations (1)

Fuwai Hospital; 🇨🇳 Beijing, China