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临床试验/NCT06387940
NCT06387940已完成不适用

Investigation Into the Postprandial Effects of Varying Calorie Content of Low-Carbohydrate Diets on Human Metabolic Health

University of Surrey2 个研究点 分布在 1 个国家目标入组 12 人开始时间: 2019年11月5日最近更新:
适应症

试验速览

阶段
不适用
状态
已完成
入组人数
12
试验地点
2
主要终点
Biomarkers in blood Measured

研究概览

简要总结

This study investigates how different low-carbohydrate diets affect metabolism and hunger in overweight adults. We will measure metabolic rates and blood metabolites.

详细描述

Participants will engage in three distinct eating plans: a standard diet with usual carbohydrate and calorie levels, a low-carb diet with typical calories, and a low-carb diet with reduced calories. Each diet is followed for a single day, with subsequent monitoring to assess how the body processes food and manages hunger after a meal. The goal is to understand the potential metabolic benefits of reducing carbohydrate intake, either alone or in combination with calorie reduction. This research aims to identify simpler dietary strategies that could improve heart health and assist in weight management without the need for severe calorie restriction or fasting, offering valuable insights for enhancing health outcomes in overweight individuals.

研究设计

研究类型
Interventional
分配方式
Randomized
干预模型
Crossover
主要目的
Supportive Care
盲法
None

入排标准

年龄范围
20 Years 至 65 Years(Adult, Older Adult)
性别
All
接受健康志愿者

入选标准

  • stable weight within ±3 kg over the past three months
  • no significant medical history.

排除标准

  • pregnancy
  • breastfeeding,
  • using medications that could affect the study's outcomes
  • high intake of caffeine and alcohol
  • existing eating or psychiatric disorders
  • adherence to strict dietary regimens like veganism
  • high BMI resulting from significant muscle mass

结局指标

主要结局

Biomarkers in blood Measured

时间窗: 8 hours (fasting and post-meal)

Measured with ELISA assay and clinical analyser (INDIKO)

Resting metabolic rate

时间窗: 8 hours (fasting and post-meal)

Measured with indirect calorimetry (GEM)

次要结局

  • Perceived Appetite Scores(8 hours (fasting and post-meal))
  • Food intake(baseline and after each diet arm for 1 day)

研究者

申办方类型
Other
责任方
Sponsor

研究点 (2)

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