Investigation Into the Postprandial Effects of Varying Calorie Content of Low-Carbohydrate Diets on Human Metabolic Health
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 12
- 试验地点
- 2
- 主要终点
- Biomarkers in blood Measured
研究概览
简要总结
This study investigates how different low-carbohydrate diets affect metabolism and hunger in overweight adults. We will measure metabolic rates and blood metabolites.
详细描述
Participants will engage in three distinct eating plans: a standard diet with usual carbohydrate and calorie levels, a low-carb diet with typical calories, and a low-carb diet with reduced calories. Each diet is followed for a single day, with subsequent monitoring to assess how the body processes food and manages hunger after a meal. The goal is to understand the potential metabolic benefits of reducing carbohydrate intake, either alone or in combination with calorie reduction. This research aims to identify simpler dietary strategies that could improve heart health and assist in weight management without the need for severe calorie restriction or fasting, offering valuable insights for enhancing health outcomes in overweight individuals.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Supportive Care
- 盲法
- None
入排标准
- 年龄范围
- 20 Years 至 65 Years(Adult, Older Adult)
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •stable weight within ±3 kg over the past three months
- •no significant medical history.
排除标准
- •pregnancy
- •breastfeeding,
- •using medications that could affect the study's outcomes
- •high intake of caffeine and alcohol
- •existing eating or psychiatric disorders
- •adherence to strict dietary regimens like veganism
- •high BMI resulting from significant muscle mass
结局指标
主要结局
Biomarkers in blood Measured
时间窗: 8 hours (fasting and post-meal)
Measured with ELISA assay and clinical analyser (INDIKO)
Resting metabolic rate
时间窗: 8 hours (fasting and post-meal)
Measured with indirect calorimetry (GEM)
次要结局
- Perceived Appetite Scores(8 hours (fasting and post-meal))
- Food intake(baseline and after each diet arm for 1 day)
