Diabetes and Metabolic Postprandial Responses

Not Applicable

Completed

• Conditions: Type 2 Diabetes; Overweight
• Interventions: Other: oral glucose load

• Registration Number: NCT00767208
• Lead Sponsor: Centre de Recherche en Nutrition Humaine Rhone-Alpe

Brief Summary

The aim of this trial was to compare postprandial metabolic response to glucose load in healthy overweight and type 2 diabetic subjects, by using glycemia, insulinemia, lipid profile, nutrient oxidation follow-up. Stable isotopes of glucose were used to assess postprandial total,exogenous and endogenous glucose kinetics.

Detailed Description

Not available

Study Timeline

• Study Start: 2005-01
• Primary Completion: 2006-05
• Study Completion: 2008-05
• Study First Submitted: 2008-10-06
• Study First Submitted QC: 2008-10-06
• Study First Posted: 2008-10-07
• Status Verified: 2009-05
• Last Update Submitted: 2009-05-19
• Last Update Posted: 2009-05-20

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 24

Inclusion Criteria

• Overweight or obese volunteers
• Healthy for one group nd type 2 diabetic for the second group
• Age between 30 and 65 years old
• Total cholesterol < or = 7 mmol/l and triglycerides < or = 4 mmol/l
• For diabetic group: treated by metformin and/or sulfonylurea and/or thiazolidinedione and HbA1c < 6%
• Stable weight over last 3 months
• Informed consent

Exclusion Criteria

• No compliant subjects
• Participation in an other trial 2 months before starting this one
• Ward of court or under guardianship (sheltered adults)
• Person deprived of freedom by judicial or administrative decision
• Type 1 diabetes and type 2 diabetes treated bu insulin or acarbose
• Existence of a previously diagnosed pathology (other than type 2 diabetes)
• Previous gastro-intestinal pathology
• Treated by corticoids, anorexigens, weight loss medicines
• Alcoholism or severe tobacco consumption

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
type 2 diabetic subjects	oral glucose load	-
overweight healthy subjects	oral glucose load	-

Primary Outcome Measures

Name	Time	Method
Apparition of exogenous glucose in plasma in the postprandial phase and its effect on carbohydrate and lipid metabolism	6 hours postprandially

Secondary Outcome Measures

Name	Time	Method
Postprandial concentrations of glucose, non esterified fatty acids, insulin and triglycerides	6 hours postprandially
Carbohydrate and lipid oxidation	6 hours postprandially

Trial Locations

Locations (1)

Centre de Recherche En Nutrition Humaine Rhone Alpes; 🇫🇷 Lyon, France