Comparison of Postprandial Metabolic Responses Between Type 2 Diabetic and Healthy Overweight Subjects

Centre de Recherche en Nutrition Humaine Rhone-Alpe1 site in 1 country24 target enrollmentJanuary 2005

ConditionsType 2 Diabetes Overweight

Overview

Phase: Not Applicable
Intervention: Not specified
Conditions: Type 2 Diabetes
Sponsor: Centre de Recherche en Nutrition Humaine Rhone-Alpe
Enrollment: 24
Locations: 1
Primary Endpoint: Apparition of exogenous glucose in plasma in the postprandial phase and its effect on carbohydrate and lipid metabolism
Status: Completed
Last Updated: 16 years ago

Overview Investigators Eligibility Criteria Outcomes Sites Similar Trials

Overview

Brief Summary

The aim of this trial was to compare postprandial metabolic response to glucose load in healthy overweight and type 2 diabetic subjects, by using glycemia, insulinemia, lipid profile, nutrient oxidation follow-up. Stable isotopes of glucose were used to assess postprandial total,exogenous and endogenous glucose kinetics.

Registry

clinicaltrials.gov

Start Date

January 2005

End Date

May 2008

Last Updated

16 years ago

Study Type

Interventional

Study Design

Parallel

Sex

All

Investigators

Sponsor

Centre de Recherche en Nutrition Humaine Rhone-Alpe

Eligibility Criteria

Inclusion Criteria

•Overweight or obese volunteers
•Healthy for one group nd type 2 diabetic for the second group
•Age between 30 and 65 years old
•Total cholesterol \< or = 7 mmol/l and triglycerides \< or = 4 mmol/l
•For diabetic group: treated by metformin and/or sulfonylurea and/or thiazolidinedione and HbA1c \< 6%
•Stable weight over last 3 months
•Informed consent

Exclusion Criteria

•No compliant subjects
•Participation in an other trial 2 months before starting this one
•Ward of court or under guardianship (sheltered adults)
•Person deprived of freedom by judicial or administrative decision
•Type 1 diabetes and type 2 diabetes treated bu insulin or acarbose
•Existence of a previously diagnosed pathology (other than type 2 diabetes)
•Previous gastro-intestinal pathology
•Treated by corticoids, anorexigens, weight loss medicines
•Alcoholism or severe tobacco consumption

Outcomes

Primary Outcomes

Apparition of exogenous glucose in plasma in the postprandial phase and its effect on carbohydrate and lipid metabolism

Time Frame: 6 hours postprandially

Secondary Outcomes

Postprandial concentrations of glucose, non esterified fatty acids, insulin and triglycerides(6 hours postprandially)
Carbohydrate and lipid oxidation(6 hours postprandially)