Metabolic Response to Fat and Glucose
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 60
- 试验地点
- 2
- 主要终点
- Plasma level of acetyl-CoA
研究概览
简要总结
The study will compare plasma and urine post-prandial metabolomics after fat and glucose oral load according to lifestyle factors.
详细描述
The metabolic response in plasma and urine, pre- and post-load tests in people with specific dietary lifestyles will be tested. This project will focus on fat and glucose induced changes of targeted metabolic pathways that have been related to diabetes and obesity risk.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Diagnostic
- 盲法
- Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
入排标准
- 年龄范围
- 40 Years 至 65 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Healthy volunteers
- •On a stable dietary habits
排除标准
- •Pregnancy
- •Malabsorption disorders
- •Present or former cancer
- •Any oral medication that affect glucose or fat absorptions
- •Cholesterol lowering drugs (i.e. Statins)
- •other drugs: fibrates, MTX, or vitamin supplements
- •Diabetes (type 1 and type 2)
- •Alcoholism
- •Weight losing diet during the last 4 months
- •Liver diseases
- •Renal dysfunction
- •Gastric resection.
结局指标
主要结局
Plasma level of acetyl-CoA
时间窗: Changes between baseline and 2 hours
Plasma levels of branched chain amino acid
时间窗: Changes between baseline and 2 hours
Plasma Trimethylamin N-oxide
时间窗: Changes between baseline and 2 hours
Plasma glucose
时间窗: Changes between baseline and 2 hours
Plasma glucose level
时间窗: Changes between baseline and 2 hours
次要结局
- Plasma insulin(Changes between baseline and 2 hours)
- Plasma Lactate(Changes between baseline and 2 hours)
- Plasma leptin(Changes between baseline and 2 hours)
- Plasma malonyl-CoA(Changes between baseline and 2 hours)
- Plasma phosphatidylcholine(Changes between baseline and 2 hours)
- Plasma pyruvate(Changes between baseline and 2 hours)
研究者
Rima Obeid
Prof. (apl.) Dr.
Universität des Saarlandes