Quantitative Assessment of Radiation-induced Neuroinflammation - A Proof of Principle Study
- Conditions
- Brain TumorMedulloblastoma
- Registration Number
- NCT05128903
- Lead Sponsor
- St. Jude Children's Research Hospital
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Active, not recruiting
- Sex
- All
- Target Recruitment
- 22
Inclusion Criteria<br><br> - Participant is at least 8 years of age<br><br> - Participants with histologically confirmed medulloblastoma and are scheduled to<br> receive 36 Gy craniospinal irradiation<br><br> - Participant and/or guardian can understand and is willing to sign a written informed<br> consent document according to institutional guidelines<br><br> - Subjects have either have high-affinity or mixed-affinity TSPO binding sites as<br> determined by the single-nucleotide polymorphism (SNP) rs6971 in the TSPO gene.<br><br>Exclusion Criteria:<br><br> - Participants with a large pseudomeningocele (>4 cm in size) at the surgical site,<br> complications from ventricular access (evidenced by hemorrhage and/or enhancement<br> along the catheter), large subdural effusion in the supra-tentorial compartment (>1<br> cm in the maximum transverse dimension). All of these are expected to induce<br> inflammation.<br><br> - Female participants of childbearing age must not be lactating due to theoretical<br> potential harm to the infant from exposure to radiation.<br><br> - Subjects with low-affinity TSPO binding sites as determined by the single-nucleotide<br> polymorphism (SNP) rs6971 in the TSPO gene.<br><br> - Pregnant subjects.<br><br> - Patients needing sedation for the PET scans.
Not provided
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method SUVr;SUVr;SUVr;SUVr;SUVr;SUVr;SUVr;SUVr;SUVr;SUVr;SUVr;SUVr;SUVr;SUVr;SUVr;SUVr;SUVr;SUVr
- Secondary Outcome Measures
Name Time Method