Predicting steroid responsiveness in patients with asthma using exhaled breath profiling.

Not Applicable

Completed

• Conditions: Asthma; Respiratory - Asthma

• Registration Number: ACTRN12613000038796
• Lead Sponsor: Otago Respiratory Research Trust

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2013-01-14
• Last Update Posted: 13 January 2020

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 45

Inclusion Criteria

Patients with mild to moderate doctors diagnosed asthma and healthy controls participate.

Exclusion Criteria

Subjects were excluded if they had experienced any respiratory tract infection or had used oral prednisone during the previous 4 weeks.

healthy controls were non-atopic and non-asthmatic, and had negative skin prick allergen tests, FENO <25ppb, no evidence of airways hyper-responsiveness to hypertonic saline, and no reversibility to bronchodilator.

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
An algorithm showing the potential of the electronic nose to discriminate between steroid responsive and unresponsive patients. [This will be assessed after 14days of steroid treatment.]

Secondary Outcome Measures

Name	Time	Method
The potential of the eNose to discriminate between patients reaching loss of control after steroid withdrawal and those not.<br><br>[After reaching personalized loss of control criteria or a maximum of 28days after steroid withdrawal <br><br>];And an algorithm showing the potential of VOC analysis to discriminate healthy controls from subjects with asthma regardless of treatment status.[Both after reaching loss of control criteria or a maximum of 28days after steroid withdrawal and after treatment.]