Predicting corticosteroid response in inflammatory neuropathies

• Conditions: inflammatory demyelinating neuropathy; neuropathy; 10034606

• Registration Number: NL-OMON33384
• Lead Sponsor: Academisch Medisch Centrum

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 6 May 2024

Recruitment & Eligibility

• Status: Pending
• Sex: Not specified
• Target Recruitment: 6

Inclusion Criteria

- Adult patients ><= 18 years; healthy controls ><= 18 and <<= 45 years
- Fulfilment of the EFNS/PNS clinical criteria for probable or definite CIDP or MADSAM (appendix in protocol)
- Disability or progression of disease justifying treatment

Exclusion Criteria

- Other diseases known to cause neuropathy
- Use of drugs which are known to cause neuropathy
- Neurophysiological evidence of carpal tunnel syndrome
- Use of immunomodulatory drugs in the last 6 months or IVIg in the last 2 months.
- Refusal to give informed consent or withdrawal of previously given permission
- Legally incompetent adult

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>1. Change in excitability indicating hyperpolarization<br /><br>2. Change in severity and number of conduction blocks </p><br>

Secondary Outcome Measures

Name	Time	Method
<p>1. Conduction velocity<br /><br>2. MRC sum score (muscle strength)<br /><br>3. INCAT sensory sum score (sensory deficit score)<br /><br>4. ALDS (Amsterdam Linear Disability Scale)<br /><br>5. INCAT disability scale (a frequently used disability scale in inflammatory<br /><br>neuroapathies)<br /><br>6. any adverse event or reaction</p><br>