A clinical trial to study the effects of two preparations, Ketamine with normal saline and only normal saline in patients receiving general anaesthesia.

Phase 4

Completed

• Conditions: Health Condition 1: O- Medical and SurgicalHealth Condition 2: null- Postoperative sore throat; General anaesthesia

• Registration Number: CTRI/2011/07/001902
• Lead Sponsor: Department of Anaesthesia and Intensive care

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Last Update Posted: 24 November 2021

Recruitment & Eligibility

• Status: Completed
• Sex: Not specified
• Target Recruitment: 60

Inclusion Criteria

American society of anesthesiologist (ASA) I?II

General anaesthesia with endotracheal intubation

Exclusion Criteria

Patients with a history of preoperative sore throat

oral surgeries

asthma

chronic obstructive pulmonary disease (COPD)

raised intracranial pressure

Mallampati grade 2

known allergies to study drug

recent NSAID medication

those who required more than one attempt at intubation

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Assesment of sore throat in adult patients undergoing surgery under general anaesthesia at pre nebulization (T0), pre induction (T1),immediate recovery (T2),two hours (T3), four hours (T4), six hours (T5),eight hours (T6),twelve hours(T7) and twenty four hours (T8) post operatively and graded on a four-point scale (0?3).Presuming the incidence of postoperative sore throat to be 65%, to show a 50% reduction in the incidence.Timepoint: Outcome Name: Postoperative sore throat at pre nebulization (T0), pre induction (T1),immediate recovery (T2),two hours (T3), four hours (T4), six hours (T5),eight hours (T6),twelve hours(T7) and twenty four hours (T8) post operatively.

Secondary Outcome Measures

Name	Time	Method
Any other side effectsTimepoint: 06 months