Study of Venous Thromboembolism Risk Profiles and Prophylaxis in Neurosurgical Inpatients
- Conditions
- Venous Thromboembolism
- Registration Number
- NCT04257305
- Lead Sponsor
- Huashan Hospital
- Brief Summary
Venous thromboembolism (VTE), comprising deep venous thrombosis (DVT), pulmonary embolism (PE), or both, is a life-threatening complication in postoperative patients. VTE has been estimated an incidence ranged from 79 per 100000 to 269 per 100000 population1. The incidence of VTE rises up to 3.0% in average among all postoperative neurosurgical patients in recent studies, but the number varies in a large range according to primary diseases. This cross-sectional study was aimed to investigate the incidence, associated risk factors, prophylaxis, treatment, and outcomes of VTE in a large clinical neurosurgery center in China.
- Detailed Description
Venous thromboembolism (VTE), comprising deep venous thrombosis (DVT), pulmonary embolism (PE), or both, is a life-threatening complication in postoperative patients. This cross-sectional study was aimed to investigate the incidence, associated risk factors, prophylaxis, treatment, and outcomes of VTE in a large clinical neurosurgery center in China. 9010 patients underwent neurosurgery procedure were included. Distribution of age, sex, whether received PICC during perioperative period, and some special primary diseases are significantly different between VTE and non-VTE patients. Student's test and chi-square test were performed for analyses. We investigated VTE incidence, risk factors, prophylaxes, treatment and outcomes in postoperative neurosurgical patients, and summarized the VTE susceptible population of the patients, providing a VTE patient profile for neurosurgeons to concern.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 9010
Neurosurgical Inpatients. Underwent neurosurgery procedure.
Acute or chronic respiratory failure. Acute myocardial infarction or other serious heart diseases.
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Rate of VTE occurrence 19 months VTE incidence in postoperative neurosurgical patients during inhospital time from Jun 1,2018 to Dec 31,2019
- Secondary Outcome Measures
Name Time Method Rate of partial vessel recanalization rate 19 months Partial vessel recanalization rate in postoperative neurosurgical patients during inhospital time from Jun 1,2018 to Dec 31,2019
Rate of complete vessel recanalization 19 months Complete vessel recanalization rate in postoperative neurosurgical patients during inhospital time from Jun 1,2018 to Dec 31,2019
Rate of bleeding events 19 months Bleeding events occurred in patients during VTE treatment
Trial Locations
- Locations (1)
Huashan hospital,Fudan university
🇨🇳Shanghai, Shanghai, China