Effects of Moxonidine Administration on Serum Neuropeptide Y Levels in Hypertensive Individuals: A Prospective Observational Study
试验速览
- 阶段
- 4 期
- 状态
- 已完成
- 入组人数
- 90
- 主要终点
- serum Neuropeptide Y levels
研究概览
简要总结
Treatment with monotherapy of moxonidine 0.6 mg daily in treatment-naïve subjects with mild or moderate hypertension
详细描述
Treatment with 0.6 mg moxonidine daily in treatment-naïve subjects with mild or moderate hypertension according to guidelines (Stage 1: Systolic Blood Pressure =140-159 mmHg, Diastolic Blood Pressure =90-99 mmHg, and Stage 2: systolic blood pressure=160-179 mmHg, diastolic blood pressure=100-109 mmHg) that require monotherapy and reevaluation after 12 weeks
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 25 Years 至 75 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •treatment-naïve subjects with mild or moderate hypertension according to Joint National Committee 7 and European Society Hypertension / European Society Cardiology 2008 (Stage 1: Systolic Blood Pressure =140-159 mmHg, Diastolic Blood Pressure =90-99 mmHg, and Stage 2: Systolic=160-179 mmHg, Diastolic=100-109 mmHg) that require monotherapy
排除标准
- •age beyond 25-75 years,
- •not taking currently anti-hypertensive medication
- •not taking anti-diabetic or lipid lowering medication and other diseases or conditions that may influence blood pressure, heart rate and catecholamines' and Neuropeptide Y levels, including anemia, fever, stage III hypertension, coronary artery disease, recent (less than 6 months) myocardial infraction or stroke, heart failure, secondary hypertension, diabetes mellitus, abnormal thyroid status or other obesity-related endocrinopathies, pregnancy, kidney failure, alcohol abuse, malignancies, depression or other psychiatric illnesses, such as schizophrenia,
研究组 & 干预措施
Group
0.6 mg moxonidine daily
干预措施: Moxonidine (Drug)
结局指标
主要结局
serum Neuropeptide Y levels
时间窗: 12 weeks
ELISA
systolic blood pressure
时间窗: 12 weeks
mmHg
diastolic blood pressure
时间窗: 12 weeks
mmHg
次要结局
- Weight(12 weeks)
- LDL Cholesterol(12 weeks)
- HDL Cholesterol(12 weeks)
- Serum triglycerides(12 weeks)
- Total Cholesterol(12 weeks)
- Body Mass Index(12 weeks)
研究者
Prof. Triantafyllos Didangelos
Associate Professor of Internal Medicine-Diabetology
Aristotle University Of Thessaloniki