MELA Study - Hedonic Study on the Taste of Drugs Crushed in Food: Observational Study Involving 16 Healthy Volunteers

Phase 1

Completed

• Conditions: Healthy
• Interventions: Other: Jelly with Furosemide; Other: Jelly with Levothyroxine sodium salt; Other: Jelly with Memantine; Other: Jelly with Zopiclone; Other: Jelly with Alprazolam; Other: Jelly with Oxazepam; Other: Jelly with Donepezil; Other: Jelly with Clopidogrel; Other: Jelly with Ramipril; Other: Jelly with Paracetamol + Furosemide + Levothyroxine sodium salt + Memantine + Zopiclone + Alprazolam; Other: Plain jelly control; Other: Apple compote Paracetamol; Other: Apple compote Furosemide; Other: Apple compote Levothyroxine sodium salt; Other: Apple compote Memantine; Other: Apple compote Zopiclone; Other: Apple compote Oxazepam; Other: Apple compote Alprazolam; Other: Apple compote Donepezil; Other: Apple compote Clopidogrel; Other: Apple compote Ramipril; Other: Apple compote + Paracetamol + Furosemide + Levothyroxine sodium salt + Memantine + Zopiclone + Alprazolam; Other: Plain apple compote control

• Registration Number: NCT02570581
• Lead Sponsor: Centre Hospitalier Universitaire de Nice

Brief Summary

Elderly people often suffer from chronic pathologies and they are given polypharmacy. In case of swallowing problems, the drugs are crushed and mixed in food, which alters the taste of food and is a cause of anorexia and malnutrition. Gustative side-effects of crushed drugs have nether been investigated. The MELA study is a one session hedonic test involving 16 healthy volunteers. They will score in a blind manner the taste of 10 drugs commonly prescribed in nursing homes, crushed in jelly or apple compote. These volunteers will be 8 food professionals and 8 geriatric care professionals. Thanks to the MELA protocol, they will have a unique opportunity to communicate and propose solutions to this neglected aspect of malnutrition in elderly populations.

Detailed Description

Background. Elderly people often suffer from chronic pathologies and they are given polypharmacy. In nursing homes, the residents take an average number of 6 to 8 active principles / day (Reference Geriatrics ward, Nice University Hospital, France), the equivalent of 10 to 20 medicines / day. But 40 % of the residents have swallowing disorders or cognitive impairment: the nursing staff is obliged to crush tablets and capsules and to give them mixed in a compote, a dairy or a jelly, for instance. Some experts groups (OMEDIT) have published a list of drugs authorized to be crushed, because this practice can modify the pharmacokinetics of certain active principles, and render them inactive or even toxic. However, the gustative aspect of crushed drugs has never been investigated.

Main objective. To identify from the advice of healthy volunteers, on the gustative aspect, which medicine it is acceptable or not recommended to add once crushed or opened in food.

Secondary objective. To search for alternative solutions. Type of study. Phase I study on healthy volunteers. It is a cohort study, with a hedonic, descriptive test in a single group and a single one session, to test the taste of 10 drugs crushed in some jelly and apple compote.

Volunteers participating in the study will be 16 healthy volunteers: 8 professionals of the restaurant, the catering, the food aromas, the nutrition and the dietetics, and 8 doctors, pharmacists, dental surgeons, nurses and/or nurse's aides.

Inclusion criteria: healthy volunteers over 18 years, without allergy known about 10 drugs to be tested. Pregnant women will not be included.

Criteria of evaluation:

1. Quantitative: mark from 0 (bad taste) to 10 (no taste or no unpleasant taste) for the jelly and compote specimens mixed with crushed drugs.

2. Qualitative: description of the perceived aroma (acid, bitter, sweet, salty, astringent, pricking, aromatic).

Brief description of the methodology:

The investigator shall test 10 drugs the most prescribed in the Korian group nursing homes, identified as being able to be crushed or opened. The assay will take place during a single one-morning session in a room specifically dedicated to clinical assays and with the help of a nursing staff trained for clinical assays (Nice University Hospital). Medicine will be crushed in parallel in some jelly and apple compote: 10 single drugs, 1 mixture of 6 drugs and 1 comparator (unmodified plain jelly and compote). Every volunteer will make these 24 tests blind and will fill a scoring sheet. He or she will spit out and have an oral rinse with some water between two tests; the dose susceptible to be ingested will be about 1/500th of a unit dosage. Excepted a risk of allergy, the medical risk is thus unimportant for the tasters. Unblinding will take place immediately after the end of the test. Every volunteer will propose alternative solutions.

Individual duration of the study. One morning. Total duration of the study. One year and half, for the organization of the test and the publication of the results.

Expected fallout

* The fight against senile anorexia and malnutrition, in elderly people who are given polypharmacy, by improving care protocols.

* Proposal of alternative solutions such as pediatric or galenic forms if they exist, other food substrates or new additives which would allow to mask the taste of certain drugs crushed in food.

* Incitement in a policy of reduction of drugs for the elderly.

Study Timeline

• Study Start: 2014-06
• Primary Completion: 2014-07
• Study Completion: 2014-07
• Status Verified: 2015-09
• Study First Submitted: 2015-09-29
• Study First Submitted QC: 2015-10-06
• Last Update Submitted: 2015-10-06
• Study First Posted: 2015-10-07
• Last Update Posted: 2015-10-07

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 16

Inclusion Criteria

• healthy volunteers over 18 years.

Exclusion Criteria

• pregnant women. Women in age to borne children will perform a urinary test will just before the assay, under the supervision of the Clinical Research Center nurse.

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Arm && Interventions

Group	Intervention	Description
Apple compote Furosemide	Jelly with Oxazepam	Apple compote Furosemide
Apple compote Furosemide	Jelly with Donepezil	Apple compote Furosemide
Apple compote Memantine	Jelly with Memantine	Apple compote Memantine
Apple compote Oxazepam	Apple compote Donepezil	Apple compote Oxazepam
Apple compote Ramipril	Jelly with Donepezil	Apple compote Ramipril
Apple compote Zopiclone	Apple compote Oxazepam	Apple compote Zopiclone
Apple compote Alprazolam	Jelly with Ramipril	Apple compote Alprazolam
Apple compote Alprazolam	Plain jelly control	Apple compote Alprazolam
Apple compote Oxazepam	Jelly with Zopiclone	Apple compote Oxazepam
Apple compote Oxazepam	Jelly with Oxazepam	Apple compote Oxazepam
Apple compote Oxazepam	Jelly with Ramipril	Apple compote Oxazepam
Apple compote Oxazepam	Apple compote Paracetamol	Apple compote Oxazepam
Apple compote Oxazepam	Apple compote Alprazolam	Apple compote Oxazepam
Apple compote Donepezil	Jelly with Furosemide	Apple compote Donepezil
Apple compote Donepezil	Jelly with Alprazolam	Apple compote Donepezil
Apple compote Donepezil	Jelly with Donepezil	Apple compote Donepezil
Apple compote Donepezil	Jelly with Clopidogrel	Apple compote Donepezil
Apple compote Donepezil	Jelly with Ramipril	Apple compote Donepezil
Apple compote Donepezil	Apple compote Paracetamol	Apple compote Donepezil
Apple compote Clopidogrel	Apple compote Oxazepam	Apple compote Clopidogrel
Apple compote Ramipril	Apple compote Zopiclone	Apple compote Ramipril
Apple compote Paracetamol	Apple compote Clopidogrel	Apple compote Paracetamol
Apple compote Furosemide	Jelly with Furosemide	Apple compote Furosemide
Apple compote Furosemide	Jelly with Memantine	Apple compote Furosemide
Jelly with Levothyroxine sodium salt	Apple compote Clopidogrel	Jelly with Levothyroxine sodium salt
Plain apple compote control	Jelly with Donepezil	Plain apple compote control
Plain apple compote control	Jelly with Clopidogrel	Plain apple compote control
Plain apple compote control	Apple compote Paracetamol	Plain apple compote control
Apple compote Levothyroxine sodium salt	Jelly with Levothyroxine sodium salt	Apple compote Levothyroxine sodium salt
Plain jelly control	Apple compote Memantine	Plain jelly control
Plain jelly control	Apple compote Ramipril	Plain jelly control
jelly with zopiclone	Jelly with Donepezil	Jelly with zopiclone
jelly with zopiclone	Apple compote Furosemide	Jelly with zopiclone
Jelly with: Paracetamol	Apple compote Furosemide	Jelly with: Paracetamol
jelly with zopiclone	Apple compote Alprazolam	Jelly with zopiclone
Jelly with Furosemide	Jelly with Ramipril	Jelly with Furosemide
Jelly with Furosemide	Apple compote Oxazepam	Jelly with Furosemide
jelly with donepezil	Apple compote Memantine	jelly with donepezil
jelly with Oxazepam	Jelly with Levothyroxine sodium salt	Jelly with Oxazepam
Plain jelly control	Jelly with Furosemide	Plain jelly control
jelly with donepezil	Apple compote Donepezil	jelly with donepezil
Jelly with clopidogrel	Apple compote Ramipril	jelly with clopidogrel
jelly with ramipril	Jelly with Furosemide	jelly with ramipril
jelly with donepezil	Plain apple compote control	jelly with donepezil
Apple compote Clopidogrel	Jelly with Alprazolam	Apple compote Clopidogrel
Jelly with clopidogrel	Jelly with Zopiclone	jelly with clopidogrel
Jelly with clopidogrel	Jelly with Oxazepam	jelly with clopidogrel
jelly with ramipril	Jelly with Donepezil	jelly with ramipril
Apple compote Clopidogrel	Jelly with Clopidogrel	Apple compote Clopidogrel
Jelly with: Paracetamol	Jelly with Ramipril	Jelly with: Paracetamol
Plain jelly control	Jelly with Donepezil	Plain jelly control
Plain jelly control	Jelly with Clopidogrel	Plain jelly control
Plain jelly control	Jelly with Ramipril	Plain jelly control
Plain jelly control	Apple compote Paracetamol	Plain jelly control
Plain jelly control	Jelly with Oxazepam	Plain jelly control
Plain jelly control	Apple compote Furosemide	Plain jelly control
Jelly with: Paracetamol	Jelly with Paracetamol + Furosemide + Levothyroxine sodium salt + Memantine + Zopiclone + Alprazolam	Jelly with: Paracetamol
jelly with zopiclone	Apple compote + Paracetamol + Furosemide + Levothyroxine sodium salt + Memantine + Zopiclone + Alprazolam	Jelly with zopiclone
Plain jelly control	Apple compote Levothyroxine sodium salt	Plain jelly control
Plain jelly control	Apple compote Oxazepam	Plain jelly control
Plain jelly control	Jelly with Zopiclone	Plain jelly control
Plain jelly control	Apple compote Clopidogrel	Plain jelly control
Jelly with: Paracetamol	Plain jelly control	Jelly with: Paracetamol
Jelly with: Paracetamol	Apple compote Zopiclone	Jelly with: Paracetamol
Jelly with: Paracetamol	Apple compote Clopidogrel	Jelly with: Paracetamol
Jelly with Levothyroxine sodium salt	Apple compote Paracetamol	Jelly with Levothyroxine sodium salt
Jelly with: Paracetamol	Apple compote Paracetamol	Jelly with: Paracetamol
Plain jelly control	Jelly with Levothyroxine sodium salt	Plain jelly control
Plain jelly control	Jelly with Memantine	Plain jelly control
Plain jelly control	Jelly with Alprazolam	Plain jelly control
Jelly with: Paracetamol	Jelly with Furosemide	Jelly with: Paracetamol
Jelly with: Paracetamol	Jelly with Levothyroxine sodium salt	Jelly with: Paracetamol
Jelly with: Paracetamol	Jelly with Alprazolam	Jelly with: Paracetamol
jelly with alprazolam	Jelly with Levothyroxine sodium salt	elly with alprazolam
Plain jelly control	Jelly with Paracetamol + Furosemide + Levothyroxine sodium salt + Memantine + Zopiclone + Alprazolam	Plain jelly control
Plain jelly control	Apple compote Zopiclone	Plain jelly control
Plain jelly control	Apple compote Alprazolam	Plain jelly control
Plain jelly control	Apple compote Donepezil	Plain jelly control
Plain jelly control	Apple compote + Paracetamol + Furosemide + Levothyroxine sodium salt + Memantine + Zopiclone + Alprazolam	Plain jelly control
Plain jelly control	Plain apple compote control	Plain jelly control
Jelly with: Paracetamol	Apple compote Memantine	Jelly with: Paracetamol
Jelly with: Paracetamol	Plain apple compote control	Jelly with: Paracetamol
Jelly with Levothyroxine sodium salt	Jelly with Memantine	Jelly with Levothyroxine sodium salt
Jelly with: Paracetamol	Jelly with Zopiclone	Jelly with: Paracetamol
Jelly with: Paracetamol	Jelly with Oxazepam	Jelly with: Paracetamol
Jelly with: Paracetamol	Jelly with Donepezil	Jelly with: Paracetamol
Jelly with: Paracetamol	Jelly with Clopidogrel	Jelly with: Paracetamol
Jelly with: Paracetamol	Apple compote Levothyroxine sodium salt	Jelly with: Paracetamol
Jelly with: Paracetamol	Apple compote Alprazolam	Jelly with: Paracetamol
Jelly with: Paracetamol	Apple compote Donepezil	Jelly with: Paracetamol
Jelly with: Paracetamol	Apple compote Ramipril	Jelly with: Paracetamol
Jelly with Furosemide	Jelly with Memantine	Jelly with Furosemide
Jelly with Furosemide	Jelly with Zopiclone	Jelly with Furosemide
Jelly with Furosemide	Plain jelly control	Jelly with Furosemide
Jelly with Furosemide	Apple compote Levothyroxine sodium salt	Jelly with Furosemide
Jelly with: Paracetamol	Jelly with Memantine	Jelly with: Paracetamol
Jelly with: Paracetamol	Apple compote Oxazepam	Jelly with: Paracetamol
Jelly with: Paracetamol	Apple compote + Paracetamol + Furosemide + Levothyroxine sodium salt + Memantine + Zopiclone + Alprazolam	Jelly with: Paracetamol
Jelly with Furosemide	Jelly with Clopidogrel	Jelly with Furosemide
Jelly with Furosemide	Apple compote Ramipril	Jelly with Furosemide
Jelly with Levothyroxine sodium salt	Jelly with Donepezil	Jelly with Levothyroxine sodium salt
Jelly with Levothyroxine sodium salt	Jelly with Ramipril	Jelly with Levothyroxine sodium salt
Jelly with Levothyroxine sodium salt	Apple compote Levothyroxine sodium salt	Jelly with Levothyroxine sodium salt
Jelly with Levothyroxine sodium salt	Apple compote Donepezil	Jelly with Levothyroxine sodium salt
Jelly with memantine	Apple compote Memantine	Jelly with memantine
Jelly with Furosemide	Apple compote Paracetamol	Jelly with Furosemide
Jelly with Furosemide	Apple compote Furosemide	Jelly with Furosemide
Jelly with Furosemide	Apple compote Donepezil	Jelly with Furosemide
Jelly with Levothyroxine sodium salt	Jelly with Furosemide	Jelly with Levothyroxine sodium salt
Jelly with Levothyroxine sodium salt	Jelly with Zopiclone	Jelly with Levothyroxine sodium salt
Jelly with Levothyroxine sodium salt	Jelly with Alprazolam	Jelly with Levothyroxine sodium salt
Jelly with Levothyroxine sodium salt	Jelly with Clopidogrel	Jelly with Levothyroxine sodium salt
Jelly with Levothyroxine sodium salt	Apple compote Furosemide	Jelly with Levothyroxine sodium salt
Jelly with memantine	Jelly with Levothyroxine sodium salt	Jelly with memantine
Jelly with memantine	Jelly with Zopiclone	Jelly with memantine
Jelly with Furosemide	Jelly with Alprazolam	Jelly with Furosemide
Jelly with Furosemide	Jelly with Oxazepam	Jelly with Furosemide
Jelly with Furosemide	Jelly with Donepezil	Jelly with Furosemide
Jelly with Furosemide	Jelly with Levothyroxine sodium salt	Jelly with Furosemide
Jelly with Furosemide	Apple compote Memantine	Jelly with Furosemide
Jelly with Furosemide	Apple compote + Paracetamol + Furosemide + Levothyroxine sodium salt + Memantine + Zopiclone + Alprazolam	Jelly with Furosemide
Jelly with Furosemide	Plain apple compote control	Jelly with Furosemide
Jelly with Levothyroxine sodium salt	Apple compote Memantine	Jelly with Levothyroxine sodium salt
Jelly with Levothyroxine sodium salt	Apple compote Zopiclone	Jelly with Levothyroxine sodium salt
Jelly with Levothyroxine sodium salt	Apple compote Ramipril	Jelly with Levothyroxine sodium salt
Jelly with memantine	Jelly with Alprazolam	Jelly with memantine
Jelly with Furosemide	Jelly with Paracetamol + Furosemide + Levothyroxine sodium salt + Memantine + Zopiclone + Alprazolam	Jelly with Furosemide
Jelly with Furosemide	Apple compote Zopiclone	Jelly with Furosemide
Jelly with Furosemide	Apple compote Alprazolam	Jelly with Furosemide
Jelly with Furosemide	Apple compote Clopidogrel	Jelly with Furosemide
Jelly with Levothyroxine sodium salt	Jelly with Oxazepam	Jelly with Levothyroxine sodium salt
Jelly with Levothyroxine sodium salt	Jelly with Paracetamol + Furosemide + Levothyroxine sodium salt + Memantine + Zopiclone + Alprazolam	Jelly with Levothyroxine sodium salt
Jelly with Levothyroxine sodium salt	Plain jelly control	Jelly with Levothyroxine sodium salt
Jelly with Levothyroxine sodium salt	Apple compote Oxazepam	Jelly with Levothyroxine sodium salt
Jelly with Levothyroxine sodium salt	Apple compote Alprazolam	Jelly with Levothyroxine sodium salt
Jelly with memantine	Apple compote Alprazolam	Jelly with memantine
Jelly with memantine	Apple compote Oxazepam	Jelly with memantine
jelly with zopiclone	Jelly with Furosemide	Jelly with zopiclone
jelly with zopiclone	Jelly with Alprazolam	Jelly with zopiclone
jelly with zopiclone	Jelly with Oxazepam	Jelly with zopiclone
Apple compote Paracetamol	Apple compote Memantine	Apple compote Paracetamol
jelly with alprazolam	Jelly with Memantine	elly with alprazolam
jelly with ramipril	Jelly with Oxazepam	jelly with ramipril
jelly with ramipril	Jelly with Paracetamol + Furosemide + Levothyroxine sodium salt + Memantine + Zopiclone + Alprazolam	jelly with ramipril
Jelly with Levothyroxine sodium salt	Apple compote + Paracetamol + Furosemide + Levothyroxine sodium salt + Memantine + Zopiclone + Alprazolam	Jelly with Levothyroxine sodium salt
Jelly with Levothyroxine sodium salt	Plain apple compote control	Jelly with Levothyroxine sodium salt
Jelly with memantine	Jelly with Furosemide	Jelly with memantine
Jelly with memantine	Jelly with Donepezil	Jelly with memantine
Jelly with memantine	Jelly with Paracetamol + Furosemide + Levothyroxine sodium salt + Memantine + Zopiclone + Alprazolam	Jelly with memantine
Jelly with memantine	Plain jelly control	Jelly with memantine
jelly with zopiclone	Apple compote Paracetamol	Jelly with zopiclone
Jelly with memantine	Apple compote Levothyroxine sodium salt	Jelly with memantine
Jelly with memantine	Apple compote Zopiclone	Jelly with memantine
Jelly with memantine	Apple compote Donepezil	Jelly with memantine
Jelly with memantine	Apple compote Clopidogrel	Jelly with memantine
Jelly with memantine	Apple compote + Paracetamol + Furosemide + Levothyroxine sodium salt + Memantine + Zopiclone + Alprazolam	Jelly with memantine
jelly with zopiclone	Jelly with Paracetamol + Furosemide + Levothyroxine sodium salt + Memantine + Zopiclone + Alprazolam	Jelly with zopiclone
jelly with zopiclone	Plain jelly control	Jelly with zopiclone
jelly with zopiclone	Apple compote Zopiclone	Jelly with zopiclone
jelly with alprazolam	Apple compote + Paracetamol + Furosemide + Levothyroxine sodium salt + Memantine + Zopiclone + Alprazolam	elly with alprazolam
Jelly with memantine	Jelly with Oxazepam	Jelly with memantine
Jelly with memantine	Jelly with Clopidogrel	Jelly with memantine
Jelly with memantine	Jelly with Ramipril	Jelly with memantine
Jelly with memantine	Apple compote Paracetamol	Jelly with memantine
Jelly with memantine	Apple compote Furosemide	Jelly with memantine
jelly with zopiclone	Apple compote Memantine	Jelly with zopiclone
jelly with alprazolam	Jelly with Donepezil	elly with alprazolam
jelly with alprazolam	Jelly with Ramipril	elly with alprazolam
jelly with alprazolam	Apple compote Zopiclone	elly with alprazolam
jelly with alprazolam	Apple compote Donepezil	elly with alprazolam
jelly with zopiclone	Jelly with Memantine	Jelly with zopiclone
jelly with zopiclone	Jelly with Ramipril	Jelly with zopiclone
jelly with zopiclone	Apple compote Oxazepam	Jelly with zopiclone
jelly with zopiclone	Apple compote Ramipril	Jelly with zopiclone
jelly with alprazolam	Jelly with Furosemide	elly with alprazolam
jelly with alprazolam	Apple compote Ramipril	elly with alprazolam
jelly with alprazolam	Apple compote Paracetamol	elly with alprazolam
jelly with alprazolam	Apple compote Levothyroxine sodium salt	elly with alprazolam
jelly with alprazolam	Apple compote Alprazolam	elly with alprazolam
jelly with alprazolam	Apple compote Oxazepam	elly with alprazolam
Jelly with memantine	Apple compote Ramipril	Jelly with memantine
Jelly with memantine	Plain apple compote control	Jelly with memantine
jelly with zopiclone	Jelly with Levothyroxine sodium salt	Jelly with zopiclone
jelly with zopiclone	Jelly with Clopidogrel	Jelly with zopiclone
jelly with zopiclone	Apple compote Levothyroxine sodium salt	Jelly with zopiclone
jelly with alprazolam	Jelly with Paracetamol + Furosemide + Levothyroxine sodium salt + Memantine + Zopiclone + Alprazolam	elly with alprazolam
jelly with alprazolam	Plain jelly control	elly with alprazolam
jelly with alprazolam	Apple compote Memantine	elly with alprazolam
jelly with Oxazepam	Jelly with Furosemide	Jelly with Oxazepam
jelly with zopiclone	Apple compote Donepezil	Jelly with zopiclone
jelly with zopiclone	Apple compote Clopidogrel	Jelly with zopiclone
jelly with zopiclone	Plain apple compote control	Jelly with zopiclone
jelly with Oxazepam	Jelly with Alprazolam	Jelly with Oxazepam
jelly with Oxazepam	Jelly with Donepezil	Jelly with Oxazepam
jelly with Oxazepam	Apple compote Paracetamol	Jelly with Oxazepam
jelly with Oxazepam	Apple compote Zopiclone	Jelly with Oxazepam
jelly with donepezil	Jelly with Zopiclone	jelly with donepezil
jelly with alprazolam	Jelly with Zopiclone	elly with alprazolam
jelly with alprazolam	Jelly with Oxazepam	elly with alprazolam
jelly with alprazolam	Jelly with Clopidogrel	elly with alprazolam
jelly with alprazolam	Apple compote Furosemide	elly with alprazolam
jelly with Oxazepam	Jelly with Clopidogrel	Jelly with Oxazepam
jelly with Oxazepam	Apple compote Levothyroxine sodium salt	Jelly with Oxazepam
jelly with Oxazepam	Apple compote + Paracetamol + Furosemide + Levothyroxine sodium salt + Memantine + Zopiclone + Alprazolam	Jelly with Oxazepam
jelly with donepezil	Jelly with Furosemide	jelly with donepezil
jelly with Oxazepam	Jelly with Ramipril	Jelly with Oxazepam
jelly with Paracetamol + Furosemide + Levothyroxine sodium sa	Apple compote Ramipril	Jelly with Paracetamol + Furosemide + Levothyroxine sodium salt + Memantine + Zopiclone + Alprazolam
jelly with alprazolam	Apple compote Clopidogrel	elly with alprazolam
jelly with Oxazepam	Jelly with Memantine	Jelly with Oxazepam
jelly with Oxazepam	Jelly with Paracetamol + Furosemide + Levothyroxine sodium salt + Memantine + Zopiclone + Alprazolam	Jelly with Oxazepam
jelly with Oxazepam	Apple compote Furosemide	Jelly with Oxazepam
jelly with Oxazepam	Apple compote Alprazolam	Jelly with Oxazepam
jelly with Oxazepam	Apple compote Donepezil	Jelly with Oxazepam
jelly with Oxazepam	Apple compote Clopidogrel	Jelly with Oxazepam
jelly with alprazolam	Plain apple compote control	elly with alprazolam
jelly with Oxazepam	Apple compote Memantine	Jelly with Oxazepam
jelly with Oxazepam	Apple compote Oxazepam	Jelly with Oxazepam
jelly with Oxazepam	Apple compote Ramipril	Jelly with Oxazepam
jelly with donepezil	Jelly with Levothyroxine sodium salt	jelly with donepezil
jelly with donepezil	Apple compote Zopiclone	jelly with donepezil
jelly with donepezil	Apple compote Alprazolam	jelly with donepezil
jelly with donepezil	Apple compote Ramipril	jelly with donepezil
jelly with donepezil	Apple compote + Paracetamol + Furosemide + Levothyroxine sodium salt + Memantine + Zopiclone + Alprazolam	jelly with donepezil
Jelly with clopidogrel	Apple compote Furosemide	jelly with clopidogrel
jelly with Oxazepam	Plain apple compote control	Jelly with Oxazepam
jelly with donepezil	Jelly with Clopidogrel	jelly with donepezil
jelly with Oxazepam	Jelly with Zopiclone	Jelly with Oxazepam
jelly with Oxazepam	Plain jelly control	Jelly with Oxazepam
Jelly with clopidogrel	Apple compote Donepezil	jelly with clopidogrel
Apple compote Paracetamol	Apple compote Donepezil	Apple compote Paracetamol
Plain apple compote control	Jelly with Furosemide	Plain apple compote control
jelly with donepezil	Jelly with Memantine	jelly with donepezil
jelly with donepezil	Apple compote Furosemide	jelly with donepezil
Jelly with clopidogrel	Jelly with Memantine	jelly with clopidogrel
Jelly with clopidogrel	Jelly with Alprazolam	jelly with clopidogrel
Jelly with clopidogrel	Jelly with Ramipril	jelly with clopidogrel
Jelly with clopidogrel	Jelly with Paracetamol + Furosemide + Levothyroxine sodium salt + Memantine + Zopiclone + Alprazolam	jelly with clopidogrel
Jelly with clopidogrel	Apple compote Paracetamol	jelly with clopidogrel
Jelly with clopidogrel	Apple compote Levothyroxine sodium salt	jelly with clopidogrel
Jelly with clopidogrel	Apple compote Alprazolam	jelly with clopidogrel
jelly with ramipril	Jelly with Levothyroxine sodium salt	jelly with ramipril
jelly with ramipril	Jelly with Memantine	jelly with ramipril
jelly with ramipril	Jelly with Zopiclone	jelly with ramipril
jelly with donepezil	Jelly with Oxazepam	jelly with donepezil
jelly with donepezil	Jelly with Ramipril	jelly with donepezil
jelly with donepezil	Jelly with Paracetamol + Furosemide + Levothyroxine sodium salt + Memantine + Zopiclone + Alprazolam	jelly with donepezil
jelly with donepezil	Plain jelly control	jelly with donepezil
jelly with donepezil	Apple compote Levothyroxine sodium salt	jelly with donepezil
jelly with donepezil	Apple compote Oxazepam	jelly with donepezil
jelly with donepezil	Apple compote Clopidogrel	jelly with donepezil
Jelly with clopidogrel	Jelly with Levothyroxine sodium salt	jelly with clopidogrel
Jelly with clopidogrel	Apple compote Zopiclone	jelly with clopidogrel
Jelly with clopidogrel	Apple compote Oxazepam	jelly with clopidogrel
Jelly with clopidogrel	Apple compote + Paracetamol + Furosemide + Levothyroxine sodium salt + Memantine + Zopiclone + Alprazolam	jelly with clopidogrel
Jelly with clopidogrel	Plain apple compote control	jelly with clopidogrel
jelly with donepezil	Jelly with Alprazolam	jelly with donepezil
jelly with donepezil	Apple compote Paracetamol	jelly with donepezil
Jelly with clopidogrel	Jelly with Furosemide	jelly with clopidogrel
Jelly with clopidogrel	Jelly with Donepezil	jelly with clopidogrel
Jelly with clopidogrel	Plain jelly control	jelly with clopidogrel
Jelly with clopidogrel	Apple compote Memantine	jelly with clopidogrel
Jelly with clopidogrel	Apple compote Clopidogrel	jelly with clopidogrel
jelly with ramipril	Plain jelly control	jelly with ramipril
jelly with ramipril	Apple compote Paracetamol	jelly with ramipril
jelly with ramipril	Apple compote Memantine	jelly with ramipril
jelly with ramipril	Apple compote Alprazolam	jelly with ramipril
jelly with Paracetamol + Furosemide + Levothyroxine sodium sa	Jelly with Levothyroxine sodium salt	Jelly with Paracetamol + Furosemide + Levothyroxine sodium salt + Memantine + Zopiclone + Alprazolam
jelly with Paracetamol + Furosemide + Levothyroxine sodium sa	Apple compote Zopiclone	Jelly with Paracetamol + Furosemide + Levothyroxine sodium salt + Memantine + Zopiclone + Alprazolam
jelly with ramipril	Jelly with Alprazolam	jelly with ramipril
jelly with ramipril	Apple compote Furosemide	jelly with ramipril
jelly with ramipril	Apple compote Levothyroxine sodium salt	jelly with ramipril
jelly with ramipril	Apple compote Oxazepam	jelly with ramipril
jelly with ramipril	Apple compote Donepezil	jelly with ramipril
jelly with ramipril	Plain apple compote control	jelly with ramipril
jelly with Paracetamol + Furosemide + Levothyroxine sodium sa	Jelly with Oxazepam	Jelly with Paracetamol + Furosemide + Levothyroxine sodium salt + Memantine + Zopiclone + Alprazolam
jelly with Paracetamol + Furosemide + Levothyroxine sodium sa	Jelly with Clopidogrel	Jelly with Paracetamol + Furosemide + Levothyroxine sodium salt + Memantine + Zopiclone + Alprazolam
jelly with ramipril	Jelly with Clopidogrel	jelly with ramipril
jelly with ramipril	Apple compote Zopiclone	jelly with ramipril
jelly with ramipril	Apple compote Ramipril	jelly with ramipril
jelly with Paracetamol + Furosemide + Levothyroxine sodium sa	Jelly with Zopiclone	Jelly with Paracetamol + Furosemide + Levothyroxine sodium salt + Memantine + Zopiclone + Alprazolam
jelly with Paracetamol + Furosemide + Levothyroxine sodium sa	Jelly with Alprazolam	Jelly with Paracetamol + Furosemide + Levothyroxine sodium salt + Memantine + Zopiclone + Alprazolam
jelly with Paracetamol + Furosemide + Levothyroxine sodium sa	Jelly with Donepezil	Jelly with Paracetamol + Furosemide + Levothyroxine sodium salt + Memantine + Zopiclone + Alprazolam
jelly with Paracetamol + Furosemide + Levothyroxine sodium sa	Apple compote Furosemide	Jelly with Paracetamol + Furosemide + Levothyroxine sodium salt + Memantine + Zopiclone + Alprazolam
jelly with Paracetamol + Furosemide + Levothyroxine sodium sa	Apple compote Levothyroxine sodium salt	Jelly with Paracetamol + Furosemide + Levothyroxine sodium salt + Memantine + Zopiclone + Alprazolam
jelly with Paracetamol + Furosemide + Levothyroxine sodium sa	Apple compote Alprazolam	Jelly with Paracetamol + Furosemide + Levothyroxine sodium salt + Memantine + Zopiclone + Alprazolam
jelly with Paracetamol + Furosemide + Levothyroxine sodium sa	Apple compote Donepezil	Jelly with Paracetamol + Furosemide + Levothyroxine sodium salt + Memantine + Zopiclone + Alprazolam
jelly with Paracetamol + Furosemide + Levothyroxine sodium sa	Apple compote Clopidogrel	Jelly with Paracetamol + Furosemide + Levothyroxine sodium salt + Memantine + Zopiclone + Alprazolam
jelly with Paracetamol + Furosemide + Levothyroxine sodium sa	Plain apple compote control	Jelly with Paracetamol + Furosemide + Levothyroxine sodium salt + Memantine + Zopiclone + Alprazolam
jelly with ramipril	Apple compote Clopidogrel	jelly with ramipril
jelly with ramipril	Apple compote + Paracetamol + Furosemide + Levothyroxine sodium salt + Memantine + Zopiclone + Alprazolam	jelly with ramipril
jelly with Paracetamol + Furosemide + Levothyroxine sodium sa	Jelly with Furosemide	Jelly with Paracetamol + Furosemide + Levothyroxine sodium salt + Memantine + Zopiclone + Alprazolam
jelly with Paracetamol + Furosemide + Levothyroxine sodium sa	Jelly with Memantine	Jelly with Paracetamol + Furosemide + Levothyroxine sodium salt + Memantine + Zopiclone + Alprazolam
Plain apple compote control	Jelly with Oxazepam	Plain apple compote control
Plain apple compote control	Apple compote Zopiclone	Plain apple compote control
Plain apple compote control	Apple compote Alprazolam	Plain apple compote control
Plain apple compote control	Apple compote Oxazepam	Plain apple compote control
Apple compote Paracetamol	Jelly with Furosemide	Apple compote Paracetamol
Apple compote Paracetamol	Jelly with Donepezil	Apple compote Paracetamol
Apple compote Paracetamol	Plain jelly control	Apple compote Paracetamol
Apple compote Paracetamol	Apple compote Zopiclone	Apple compote Paracetamol
Apple compote Paracetamol	Apple compote Alprazolam	Apple compote Paracetamol
Apple compote Furosemide	Jelly with Alprazolam	Apple compote Furosemide
Apple compote Oxazepam	Apple compote Clopidogrel	Apple compote Oxazepam
jelly with Paracetamol + Furosemide + Levothyroxine sodium sa	Jelly with Ramipril	Jelly with Paracetamol + Furosemide + Levothyroxine sodium salt + Memantine + Zopiclone + Alprazolam
jelly with Paracetamol + Furosemide + Levothyroxine sodium sa	Plain jelly control	Jelly with Paracetamol + Furosemide + Levothyroxine sodium salt + Memantine + Zopiclone + Alprazolam
jelly with Paracetamol + Furosemide + Levothyroxine sodium sa	Apple compote Paracetamol	Jelly with Paracetamol + Furosemide + Levothyroxine sodium salt + Memantine + Zopiclone + Alprazolam
jelly with Paracetamol + Furosemide + Levothyroxine sodium sa	Apple compote Memantine	Jelly with Paracetamol + Furosemide + Levothyroxine sodium salt + Memantine + Zopiclone + Alprazolam
jelly with Paracetamol + Furosemide + Levothyroxine sodium sa	Apple compote + Paracetamol + Furosemide + Levothyroxine sodium salt + Memantine + Zopiclone + Alprazolam	Jelly with Paracetamol + Furosemide + Levothyroxine sodium salt + Memantine + Zopiclone + Alprazolam
Plain apple compote control	Jelly with Levothyroxine sodium salt	Plain apple compote control
Plain apple compote control	Jelly with Memantine	Plain apple compote control
Plain apple compote control	Jelly with Zopiclone	Plain apple compote control
Plain apple compote control	Jelly with Alprazolam	Plain apple compote control
Plain apple compote control	Apple compote Levothyroxine sodium salt	Plain apple compote control
Plain apple compote control	Apple compote Memantine	Plain apple compote control
Plain apple compote control	Apple compote Donepezil	Plain apple compote control
Plain apple compote control	Apple compote Clopidogrel	Plain apple compote control
Plain apple compote control	Apple compote Ramipril	Plain apple compote control
jelly with Paracetamol + Furosemide + Levothyroxine sodium sa	Apple compote Oxazepam	Jelly with Paracetamol + Furosemide + Levothyroxine sodium salt + Memantine + Zopiclone + Alprazolam
Apple compote Paracetamol	Jelly with Levothyroxine sodium salt	Apple compote Paracetamol
Apple compote Paracetamol	Jelly with Ramipril	Apple compote Paracetamol
Apple compote Paracetamol	Apple compote Furosemide	Apple compote Paracetamol
Apple compote Furosemide	Jelly with Paracetamol + Furosemide + Levothyroxine sodium salt + Memantine + Zopiclone + Alprazolam	Apple compote Furosemide
Apple compote Furosemide	Plain jelly control	Apple compote Furosemide
Apple compote Furosemide	Apple compote Paracetamol	Apple compote Furosemide
Apple compote Furosemide	Apple compote Zopiclone	Apple compote Furosemide
Apple compote Furosemide	Apple compote Alprazolam	Apple compote Furosemide
Plain apple compote control	Jelly with Ramipril	Plain apple compote control
Plain apple compote control	Jelly with Paracetamol + Furosemide + Levothyroxine sodium salt + Memantine + Zopiclone + Alprazolam	Plain apple compote control
Plain apple compote control	Plain jelly control	Plain apple compote control
Plain apple compote control	Apple compote Furosemide	Plain apple compote control
Plain apple compote control	Apple compote + Paracetamol + Furosemide + Levothyroxine sodium salt + Memantine + Zopiclone + Alprazolam	Plain apple compote control
Apple compote Paracetamol	Apple compote Levothyroxine sodium salt	Apple compote Paracetamol
Apple compote Paracetamol	Apple compote Oxazepam	Apple compote Paracetamol
Apple compote Furosemide	Jelly with Zopiclone	Apple compote Furosemide
Apple compote Furosemide	Apple compote Donepezil	Apple compote Furosemide
Apple compote Furosemide	Jelly with Clopidogrel	Apple compote Furosemide
Apple compote Oxazepam	Plain apple compote control	Apple compote Oxazepam
Apple compote Paracetamol	Jelly with Memantine	Apple compote Paracetamol
Apple compote Paracetamol	Jelly with Zopiclone	Apple compote Paracetamol
Apple compote Paracetamol	Jelly with Clopidogrel	Apple compote Paracetamol
Apple compote Furosemide	Apple compote Levothyroxine sodium salt	Apple compote Furosemide
Apple compote Furosemide	Apple compote Clopidogrel	Apple compote Furosemide
Apple compote Levothyroxine sodium salt	Jelly with Ramipril	Apple compote Levothyroxine sodium salt
Apple compote Levothyroxine sodium salt	Apple compote Paracetamol	Apple compote Levothyroxine sodium salt
Apple compote Levothyroxine sodium salt	Apple compote Ramipril	Apple compote Levothyroxine sodium salt
Apple compote Memantine	Jelly with Paracetamol + Furosemide + Levothyroxine sodium salt + Memantine + Zopiclone + Alprazolam	Apple compote Memantine
Apple compote Zopiclone	Jelly with Levothyroxine sodium salt	Apple compote Zopiclone
Apple compote Zopiclone	Jelly with Memantine	Apple compote Zopiclone
Apple compote Paracetamol	Jelly with Alprazolam	Apple compote Paracetamol
Apple compote Paracetamol	Jelly with Oxazepam	Apple compote Paracetamol
Apple compote Paracetamol	Jelly with Paracetamol + Furosemide + Levothyroxine sodium salt + Memantine + Zopiclone + Alprazolam	Apple compote Paracetamol
Apple compote Paracetamol	Apple compote Ramipril	Apple compote Paracetamol
Apple compote Paracetamol	Apple compote + Paracetamol + Furosemide + Levothyroxine sodium salt + Memantine + Zopiclone + Alprazolam	Apple compote Paracetamol
Apple compote Paracetamol	Plain apple compote control	Apple compote Paracetamol
Apple compote Furosemide	Jelly with Levothyroxine sodium salt	Apple compote Furosemide
Apple compote Levothyroxine sodium salt	Jelly with Furosemide	Apple compote Levothyroxine sodium salt
Apple compote Levothyroxine sodium salt	Jelly with Zopiclone	Apple compote Levothyroxine sodium salt
Apple compote Levothyroxine sodium salt	Jelly with Clopidogrel	Apple compote Levothyroxine sodium salt
Apple compote Clopidogrel	Apple compote + Paracetamol + Furosemide + Levothyroxine sodium salt + Memantine + Zopiclone + Alprazolam	Apple compote Clopidogrel
Apple compote Furosemide	Jelly with Ramipril	Apple compote Furosemide
Apple compote Furosemide	Apple compote Memantine	Apple compote Furosemide
Apple compote Furosemide	Apple compote Oxazepam	Apple compote Furosemide
Apple compote Furosemide	Apple compote Ramipril	Apple compote Furosemide
Apple compote Furosemide	Apple compote + Paracetamol + Furosemide + Levothyroxine sodium salt + Memantine + Zopiclone + Alprazolam	Apple compote Furosemide
Apple compote Levothyroxine sodium salt	Jelly with Alprazolam	Apple compote Levothyroxine sodium salt
Apple compote Levothyroxine sodium salt	Jelly with Oxazepam	Apple compote Levothyroxine sodium salt
Apple compote Levothyroxine sodium salt	Jelly with Donepezil	Apple compote Levothyroxine sodium salt
Apple compote Levothyroxine sodium salt	Plain jelly control	Apple compote Levothyroxine sodium salt
Apple compote Levothyroxine sodium salt	Apple compote Memantine	Apple compote Levothyroxine sodium salt
Apple compote Levothyroxine sodium salt	Apple compote Zopiclone	Apple compote Levothyroxine sodium salt
Apple compote Levothyroxine sodium salt	Apple compote Oxazepam	Apple compote Levothyroxine sodium salt
Apple compote Levothyroxine sodium salt	Apple compote Clopidogrel	Apple compote Levothyroxine sodium salt
Apple compote Levothyroxine sodium salt	Plain apple compote control	Apple compote Levothyroxine sodium salt
Apple compote Memantine	Jelly with Levothyroxine sodium salt	Apple compote Memantine
Apple compote Furosemide	Plain apple compote control	Apple compote Furosemide
Apple compote Levothyroxine sodium salt	Jelly with Memantine	Apple compote Levothyroxine sodium salt
Apple compote Levothyroxine sodium salt	Jelly with Paracetamol + Furosemide + Levothyroxine sodium salt + Memantine + Zopiclone + Alprazolam	Apple compote Levothyroxine sodium salt
Apple compote Memantine	Jelly with Alprazolam	Apple compote Memantine
Apple compote Memantine	Jelly with Ramipril	Apple compote Memantine
Apple compote Zopiclone	Jelly with Donepezil	Apple compote Zopiclone
Apple compote Zopiclone	Jelly with Clopidogrel	Apple compote Zopiclone
Apple compote Zopiclone	Apple compote Clopidogrel	Apple compote Zopiclone
Apple compote Alprazolam	Jelly with Alprazolam	Apple compote Alprazolam
Apple compote Alprazolam	Apple compote Zopiclone	Apple compote Alprazolam
Apple compote Alprazolam	Apple compote Oxazepam	Apple compote Alprazolam
Apple compote Alprazolam	Apple compote + Paracetamol + Furosemide + Levothyroxine sodium salt + Memantine + Zopiclone + Alprazolam	Apple compote Alprazolam
Apple compote Oxazepam	Jelly with Memantine	Apple compote Oxazepam
Apple compote Levothyroxine sodium salt	Apple compote Furosemide	Apple compote Levothyroxine sodium salt
Apple compote Levothyroxine sodium salt	Apple compote Alprazolam	Apple compote Levothyroxine sodium salt
Apple compote Levothyroxine sodium salt	Apple compote + Paracetamol + Furosemide + Levothyroxine sodium salt + Memantine + Zopiclone + Alprazolam	Apple compote Levothyroxine sodium salt
Apple compote Memantine	Apple compote Levothyroxine sodium salt	Apple compote Memantine
Apple compote Memantine	Apple compote Oxazepam	Apple compote Memantine
Apple compote Zopiclone	Jelly with Oxazepam	Apple compote Zopiclone
Apple compote Zopiclone	Jelly with Paracetamol + Furosemide + Levothyroxine sodium salt + Memantine + Zopiclone + Alprazolam	Apple compote Zopiclone
Apple compote Zopiclone	Apple compote Paracetamol	Apple compote Zopiclone
Apple compote Zopiclone	Apple compote Memantine	Apple compote Zopiclone
Apple compote Zopiclone	Apple compote Alprazolam	Apple compote Zopiclone
Apple compote Levothyroxine sodium salt	Apple compote Donepezil	Apple compote Levothyroxine sodium salt
Apple compote Memantine	Jelly with Furosemide	Apple compote Memantine
Apple compote Memantine	Jelly with Zopiclone	Apple compote Memantine
Apple compote Memantine	Jelly with Oxazepam	Apple compote Memantine
Apple compote Memantine	Jelly with Donepezil	Apple compote Memantine
Apple compote Memantine	Jelly with Clopidogrel	Apple compote Memantine
Apple compote Memantine	Plain jelly control	Apple compote Memantine
Apple compote Memantine	Apple compote Paracetamol	Apple compote Memantine
Apple compote Memantine	Apple compote Furosemide	Apple compote Memantine
Apple compote Memantine	Apple compote + Paracetamol + Furosemide + Levothyroxine sodium salt + Memantine + Zopiclone + Alprazolam	Apple compote Memantine
Apple compote Zopiclone	Apple compote Levothyroxine sodium salt	Apple compote Zopiclone
Apple compote Alprazolam	Jelly with Memantine	Apple compote Alprazolam
Apple compote Alprazolam	Jelly with Oxazepam	Apple compote Alprazolam
Apple compote Donepezil	Jelly with Memantine	Apple compote Donepezil
Apple compote Memantine	Apple compote Zopiclone	Apple compote Memantine
Apple compote Memantine	Apple compote Alprazolam	Apple compote Memantine
Apple compote Memantine	Apple compote Donepezil	Apple compote Memantine
Apple compote Memantine	Apple compote Clopidogrel	Apple compote Memantine
Apple compote Memantine	Apple compote Ramipril	Apple compote Memantine
Apple compote Memantine	Plain apple compote control	Apple compote Memantine
Apple compote Zopiclone	Jelly with Furosemide	Apple compote Zopiclone
Apple compote Zopiclone	Jelly with Zopiclone	Apple compote Zopiclone
Apple compote Zopiclone	Jelly with Alprazolam	Apple compote Zopiclone
Apple compote Zopiclone	Jelly with Ramipril	Apple compote Zopiclone
Apple compote Zopiclone	Plain jelly control	Apple compote Zopiclone
Apple compote Zopiclone	Apple compote Ramipril	Apple compote Zopiclone
Apple compote Zopiclone	Plain apple compote control	Apple compote Zopiclone
Apple compote Alprazolam	Jelly with Zopiclone	Apple compote Alprazolam
Apple compote Oxazepam	Apple compote Ramipril	Apple compote Oxazepam
Apple compote Donepezil	Jelly with Zopiclone	Apple compote Donepezil
Apple compote Zopiclone	Apple compote Furosemide	Apple compote Zopiclone
Apple compote Zopiclone	Apple compote Donepezil	Apple compote Zopiclone
Apple compote Alprazolam	Jelly with Furosemide	Apple compote Alprazolam
Apple compote Alprazolam	Jelly with Levothyroxine sodium salt	Apple compote Alprazolam
Apple compote Alprazolam	Jelly with Paracetamol + Furosemide + Levothyroxine sodium salt + Memantine + Zopiclone + Alprazolam	Apple compote Alprazolam
Apple compote Alprazolam	Apple compote Levothyroxine sodium salt	Apple compote Alprazolam
Apple compote Alprazolam	Apple compote Donepezil	Apple compote Alprazolam
Apple compote Alprazolam	Apple compote Ramipril	Apple compote Alprazolam
Apple compote Oxazepam	Jelly with Alprazolam	Apple compote Oxazepam
Apple compote Oxazepam	Jelly with Paracetamol + Furosemide + Levothyroxine sodium salt + Memantine + Zopiclone + Alprazolam	Apple compote Oxazepam
Apple compote Oxazepam	Apple compote Memantine	Apple compote Oxazepam
Apple compote Donepezil	Jelly with Paracetamol + Furosemide + Levothyroxine sodium salt + Memantine + Zopiclone + Alprazolam	Apple compote Donepezil
Apple compote Zopiclone	Apple compote + Paracetamol + Furosemide + Levothyroxine sodium salt + Memantine + Zopiclone + Alprazolam	Apple compote Zopiclone
Apple compote Alprazolam	Apple compote Paracetamol	Apple compote Alprazolam
Apple compote Alprazolam	Apple compote Furosemide	Apple compote Alprazolam
Apple compote Alprazolam	Apple compote Memantine	Apple compote Alprazolam
Apple compote Alprazolam	Plain apple compote control	Apple compote Alprazolam
Apple compote Oxazepam	Jelly with Donepezil	Apple compote Oxazepam
Apple compote Oxazepam	Apple compote Levothyroxine sodium salt	Apple compote Oxazepam
Apple compote Oxazepam	Apple compote Zopiclone	Apple compote Oxazepam
Apple compote Donepezil	Jelly with Oxazepam	Apple compote Donepezil
Apple compote Alprazolam	Jelly with Donepezil	Apple compote Alprazolam
Apple compote Alprazolam	Jelly with Clopidogrel	Apple compote Alprazolam
Apple compote Oxazepam	Jelly with Clopidogrel	Apple compote Oxazepam
Apple compote Oxazepam	Plain jelly control	Apple compote Oxazepam
Apple compote Oxazepam	Apple compote Furosemide	Apple compote Oxazepam
Apple compote Oxazepam	Apple compote + Paracetamol + Furosemide + Levothyroxine sodium salt + Memantine + Zopiclone + Alprazolam	Apple compote Oxazepam
Apple compote Alprazolam	Apple compote Clopidogrel	Apple compote Alprazolam
Apple compote Oxazepam	Jelly with Furosemide	Apple compote Oxazepam
Apple compote Oxazepam	Jelly with Levothyroxine sodium salt	Apple compote Oxazepam
Apple compote Donepezil	Apple compote Memantine	Apple compote Donepezil
Apple compote Donepezil	Apple compote Zopiclone	Apple compote Donepezil
Apple compote Donepezil	Apple compote Alprazolam	Apple compote Donepezil
Apple compote Clopidogrel	Jelly with Zopiclone	Apple compote Clopidogrel
Apple compote Clopidogrel	Apple compote Ramipril	Apple compote Clopidogrel
Apple compote Donepezil	Jelly with Levothyroxine sodium salt	Apple compote Donepezil
Apple compote Donepezil	Apple compote Furosemide	Apple compote Donepezil
Apple compote Donepezil	Apple compote Clopidogrel	Apple compote Donepezil
Apple compote Clopidogrel	Plain jelly control	Apple compote Clopidogrel
Apple compote Clopidogrel	Apple compote Donepezil	Apple compote Clopidogrel
Apple compote Donepezil	Plain jelly control	Apple compote Donepezil
Apple compote Donepezil	Apple compote Levothyroxine sodium salt	Apple compote Donepezil
Apple compote Donepezil	Apple compote Ramipril	Apple compote Donepezil
Apple compote Donepezil	Plain apple compote control	Apple compote Donepezil
Apple compote Clopidogrel	Jelly with Levothyroxine sodium salt	Apple compote Clopidogrel
Apple compote Clopidogrel	Jelly with Donepezil	Apple compote Clopidogrel
Apple compote Clopidogrel	Jelly with Ramipril	Apple compote Clopidogrel
Apple compote Clopidogrel	Jelly with Paracetamol + Furosemide + Levothyroxine sodium salt + Memantine + Zopiclone + Alprazolam	Apple compote Clopidogrel
Apple compote Clopidogrel	Apple compote Levothyroxine sodium salt	Apple compote Clopidogrel
Apple compote Clopidogrel	Apple compote Zopiclone	Apple compote Clopidogrel
Apple compote Clopidogrel	Apple compote Alprazolam	Apple compote Clopidogrel
Apple compote Ramipril	Plain jelly control	Apple compote Ramipril
Apple compote Donepezil	Apple compote Oxazepam	Apple compote Donepezil
Apple compote Clopidogrel	Jelly with Furosemide	Apple compote Clopidogrel
Apple compote Clopidogrel	Apple compote Paracetamol	Apple compote Clopidogrel
Apple compote Clopidogrel	Plain apple compote control	Apple compote Clopidogrel
Apple compote Ramipril	Jelly with Memantine	Apple compote Ramipril
Apple compote Ramipril	Jelly with Zopiclone	Apple compote Ramipril
Apple compote Ramipril	Jelly with Alprazolam	Apple compote Ramipril
Apple compote Ramipril	Jelly with Paracetamol + Furosemide + Levothyroxine sodium salt + Memantine + Zopiclone + Alprazolam	Apple compote Ramipril
Apple compote Donepezil	Apple compote + Paracetamol + Furosemide + Levothyroxine sodium salt + Memantine + Zopiclone + Alprazolam	Apple compote Donepezil
Apple compote Clopidogrel	Jelly with Memantine	Apple compote Clopidogrel
Apple compote Clopidogrel	Jelly with Oxazepam	Apple compote Clopidogrel
Apple compote Clopidogrel	Apple compote Furosemide	Apple compote Clopidogrel
Apple compote Clopidogrel	Apple compote Memantine	Apple compote Clopidogrel
Apple compote Ramipril	Jelly with Oxazepam	Apple compote Ramipril
Apple compote Ramipril	Jelly with Clopidogrel	Apple compote Ramipril
Apple compote Ramipril	Jelly with Ramipril	Apple compote Ramipril
Apple compote Ramipril	Apple compote Memantine	Apple compote Ramipril
Apple Paracetamol Furosemide Levothyroxine NACL Memantine Zopi	Jelly with Furosemide	Apple Paracetamol Furosemide Levothyroxine NACL Memantine Zopiclone Alprazolam
Apple Paracetamol Furosemide Levothyroxine NACL Memantine Zopi	Jelly with Zopiclone	Apple Paracetamol Furosemide Levothyroxine NACL Memantine Zopiclone Alprazolam
Apple compote Ramipril	Jelly with Furosemide	Apple compote Ramipril
Apple compote Ramipril	Jelly with Levothyroxine sodium salt	Apple compote Ramipril
Apple compote Ramipril	Apple compote Paracetamol	Apple compote Ramipril
Apple compote Ramipril	Apple compote Furosemide	Apple compote Ramipril
Apple compote Ramipril	Apple compote Levothyroxine sodium salt	Apple compote Ramipril
Apple compote Ramipril	Apple compote Alprazolam	Apple compote Ramipril
Apple compote Ramipril	Apple compote Clopidogrel	Apple compote Ramipril
Apple Paracetamol Furosemide Levothyroxine NACL Memantine Zopi	Jelly with Alprazolam	Apple Paracetamol Furosemide Levothyroxine NACL Memantine Zopiclone Alprazolam
Apple Paracetamol Furosemide Levothyroxine NACL Memantine Zopi	Jelly with Oxazepam	Apple Paracetamol Furosemide Levothyroxine NACL Memantine Zopiclone Alprazolam
Apple compote Ramipril	Apple compote Oxazepam	Apple compote Ramipril
Apple compote Ramipril	Apple compote Donepezil	Apple compote Ramipril
Apple Paracetamol Furosemide Levothyroxine NACL Memantine Zopi	Jelly with Ramipril	Apple Paracetamol Furosemide Levothyroxine NACL Memantine Zopiclone Alprazolam
Apple Paracetamol Furosemide Levothyroxine NACL Memantine Zopi	Apple compote Alprazolam	Apple Paracetamol Furosemide Levothyroxine NACL Memantine Zopiclone Alprazolam
Apple compote Ramipril	Plain apple compote control	Apple compote Ramipril
Apple Paracetamol Furosemide Levothyroxine NACL Memantine Zopi	Jelly with Donepezil	Apple Paracetamol Furosemide Levothyroxine NACL Memantine Zopiclone Alprazolam
Apple Paracetamol Furosemide Levothyroxine NACL Memantine Zopi	Apple compote Paracetamol	Apple Paracetamol Furosemide Levothyroxine NACL Memantine Zopiclone Alprazolam
Apple compote Ramipril	Apple compote + Paracetamol + Furosemide + Levothyroxine sodium salt + Memantine + Zopiclone + Alprazolam	Apple compote Ramipril
Apple Paracetamol Furosemide Levothyroxine NACL Memantine Zopi	Jelly with Levothyroxine sodium salt	Apple Paracetamol Furosemide Levothyroxine NACL Memantine Zopiclone Alprazolam
Apple Paracetamol Furosemide Levothyroxine NACL Memantine Zopi	Jelly with Memantine	Apple Paracetamol Furosemide Levothyroxine NACL Memantine Zopiclone Alprazolam
Apple Paracetamol Furosemide Levothyroxine NACL Memantine Zopi	Jelly with Clopidogrel	Apple Paracetamol Furosemide Levothyroxine NACL Memantine Zopiclone Alprazolam
Apple Paracetamol Furosemide Levothyroxine NACL Memantine Zopi	Apple compote Oxazepam	Apple Paracetamol Furosemide Levothyroxine NACL Memantine Zopiclone Alprazolam
Apple Paracetamol Furosemide Levothyroxine NACL Memantine Zopi	Apple compote Donepezil	Apple Paracetamol Furosemide Levothyroxine NACL Memantine Zopiclone Alprazolam
Apple Paracetamol Furosemide Levothyroxine NACL Memantine Zopi	Apple compote Clopidogrel	Apple Paracetamol Furosemide Levothyroxine NACL Memantine Zopiclone Alprazolam
Apple Paracetamol Furosemide Levothyroxine NACL Memantine Zopi	Jelly with Paracetamol + Furosemide + Levothyroxine sodium salt + Memantine + Zopiclone + Alprazolam	Apple Paracetamol Furosemide Levothyroxine NACL Memantine Zopiclone Alprazolam
Apple Paracetamol Furosemide Levothyroxine NACL Memantine Zopi	Plain jelly control	Apple Paracetamol Furosemide Levothyroxine NACL Memantine Zopiclone Alprazolam
Apple Paracetamol Furosemide Levothyroxine NACL Memantine Zopi	Apple compote Furosemide	Apple Paracetamol Furosemide Levothyroxine NACL Memantine Zopiclone Alprazolam
Apple Paracetamol Furosemide Levothyroxine NACL Memantine Zopi	Apple compote Levothyroxine sodium salt	Apple Paracetamol Furosemide Levothyroxine NACL Memantine Zopiclone Alprazolam
Apple Paracetamol Furosemide Levothyroxine NACL Memantine Zopi	Apple compote Memantine	Apple Paracetamol Furosemide Levothyroxine NACL Memantine Zopiclone Alprazolam
Apple Paracetamol Furosemide Levothyroxine NACL Memantine Zopi	Apple compote Zopiclone	Apple Paracetamol Furosemide Levothyroxine NACL Memantine Zopiclone Alprazolam
Apple Paracetamol Furosemide Levothyroxine NACL Memantine Zopi	Apple compote Ramipril	Apple Paracetamol Furosemide Levothyroxine NACL Memantine Zopiclone Alprazolam
Apple Paracetamol Furosemide Levothyroxine NACL Memantine Zopi	Plain apple compote control	Apple Paracetamol Furosemide Levothyroxine NACL Memantine Zopiclone Alprazolam

Primary Outcome Measures

Name	Time	Method
Quantitative- compare the taste between specimens	1 week after the test	Quantitative: mark from 0 (bad taste) to 10 (no taste or no unpleasant taste) for the jelly and compote specimens added with crushed drugs.

Secondary Outcome Measures

Name	Time	Method
qualitative - description of the perceived aroma	1 week after the test	Qualitative: description of the perceived aroma (acid, bitter, sweet, salty, astringent, pricking, aromatic).

Trial Locations

Locations (1)

Center for Clinical Research - Archet 1 Hospital Nice Hospital; 🇫🇷 Nice, France