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临床试验/NCT05424250
NCT05424250已完成不适用

Optimizing Exposure Therapy Via Occasional Aversive Imagery: A Randomized Controlled Trial With Spider Fearful Individuals

Philipps University Marburg1 个研究点 分布在 1 个国家目标入组 67 人开始时间: 2022年6月15日最近更新:
适应症

试验速览

阶段
不适用
状态
已完成
入组人数
67
试验地点
1
主要终点
Spider Phobia Questionnaire (SPQ)

研究概览

简要总结

The effectiveness of an optimized extinction training is investigated in spider-fearful individuals. Participants will undergo a one-session standardized extinction training, either with or without occasional metal imagination of most feared apprehension towards spiders. The effectiveness of the training is measured by symptom improvement according to subjective ratings and behavioural avoidance tests one week later.

详细描述

The present study aims to investigate the applicability of an optimized exposure training using imagination. Exposure training is an effective approach to the treatment of various anxiety disorders. However, there are a significant number of patients who do not benefit or who develop anxiety following successful treatment. The process of extinction underlying exposure is the focus of current research on optimizing exposure. In this regard, one promising approach for improving extinction learning involves the occasional presentation of fear-generating stimuli (unconditioned stimuli [US]; often an electrical stimulus in experimental studies) during extinction (occasional reinforced extinction, ORE). Previous experimental studies provide preliminary evidence for a less pronounced return of fear after extinction training with occasional presentation of the US. In clinical practice, this strategy is recommended to optimize extinction learning in the treatment of individuals with anxiety. However, the transfer of the procedure used (real presentation of an unconditioned stimulus) into clinical practice seems difficult to realize. One way to facilitate the transfer of the ORE approach into clinical practice could be the use of vivid imagination of a personally relevant fear-generating situation during extinction training/exposure (e.g., patients' central concerns). Therefore, the aim of the present study is to examine the applicability of ORE using imagination. In this context, a standardized extinction training either with or without mental imagination of a personally relevant fear situation (e.g., central concern of the consequences when confronted with spiders) will be performed in individuals with spider-fearful individuals. The approach used for individuals with spider fear is well established and has been successfully implemented in previous studies by instructed trainers (e.g., individuals with a bachelor's degree in psychology). The aim of this randomized controlled trial in healthy individuals with increased fear of spiders is to investigate whether optimized extinction training (extinction training + imagination) is more effective in reducing fear of spiders in the long term compared to standard extinction training.

研究设计

研究类型
Interventional
分配方式
Randomized
干预模型
Parallel
主要目的
Treatment
盲法
Triple (Participant, Investigator, Outcomes Assessor)

入排标准

年龄范围
18 Years 至 —(Adult, Older Adult)
性别
All
接受健康志愿者

入选标准

  • Elevated score on Spider Phobia Questionnaire (SPQ) > 17

排除标准

  • Severe allergies to bees/spiders/insects
  • current psychotherapeutic/psychiatric treatment
  • past psychotherapeutic/psychiatric treatment due to anxiety problems
  • current or past psychotic symptoms
  • current suicidal intent
  • experience with exposure-based treatment
  • current psychopharmacological medication
  • severe cardiovascular, respiratory or neurological diseases

结局指标

主要结局

Spider Phobia Questionnaire (SPQ)

时间窗: Change from baseline to post-treatment (i.e., 7-9 days)

31-item true/false questionnaire assessing symptoms of arachnophobia. Scores range from 0 to 31, with greater scores representing greater fear of spiders. Spider phobic individuals have obtained mean scores of 23.20 (SD = 2.90) and 23.76 (SD = 3.80) on the SPQ.

Fear rating

时间窗: Change from baseline to post-treatment (i.e., 7-9 days)

Maximum fear rating on a scale from 0 (no fear) to 100 (severe fear) recorded once during BAT

Behavioral Approach Test (BAT)

时间窗: Change from baseline to post-treatment (i.e., 7-9 days)

Number of test steps fully completed (0-14 steps)

次要结局

  • Fear of Spider Questionnaire (FSQ)(Change from baseline to post-treatment (i.e., 7-9 days))
  • Change in anxiety sensitivity (ASI-3)(change from baseline to post-treatment (i.e. 7-9 days))
  • US expectancy and fear ratings(Baseline)
  • PROMIS Emotional Distress-Anxiety-Short Form(change from baseline to post-treatment (i.e. 7-9 days))

研究者

申办方类型
Other
责任方
Principal Investigator
主要研究者

Christoph Benke

Principal Investigator

Philipps University Marburg

研究点 (1)

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