Cohort Study of Chronic Heart Failure
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Heart Failure
- Sponsor
- Jiangsu Taizhou People's Hospital
- Enrollment
- 1000
- Locations
- 1
- Primary Endpoint
- incidence of composite event (cardiovascular mortality, unplanned HF hospitalization, emergency HF intervention)
- Status
- Recruiting
- Last Updated
- 11 months ago
Overview
Brief Summary
The goal of this observational study is to learn about the influencing factors of chronic heart failure prognosis in heart failure patients. The main question it aims to answer is that what are the influencing factors of clinical outcomes in chronic heart failure. Participants will be collected multiple omics data such as phenotype group, environmental exposure group, intestinal microbiome, genome, metabolome, and noninvasive biomarkers.
Investigators
Ming Chu
The deputy dean of the hospital
Jiangsu Taizhou People's Hospital
Eligibility Criteria
Inclusion Criteria
- •Age ≥18 years;
- •Fulfill at least one of the following criteria：①History of chronic heart failure;②New-onset heart failure with LVEF \<50%；③New-onset heart failure with LVEF≧50%，E/e'≧15 and BNP\>400 pg/mL/NT-proBNP(\<50 years, \>450 pg/mL; 50\~75 years, \>900 pg/mL; \>75 years, \>1800 pg/mL)
- •Etiology: dilated cardiomyopathy, hypertensive heart disease, ischaemic cardiomyopathy, Non-severe valvular heart disease；
- •Primary post-discharge therapy: oral medication;
- •Sign the informed consent form.
Exclusion Criteria
- •Patients with renal failure (Ccr\<30ml/min) or patients on dialysis therapy;
- •Various correctable secondary causes of cardiac insufficiency including hyperthyroid heart disease, anaemic heart disease, uncorrected congenital heart disease; severe valvular heart disease (including severe stenosis or closure of organic aortic and mitral valves);
- •Patients with indications for pacemaker implantation but have not received a pacemaker implant;
- •Patients with chronic obstructive pulmonary disease accompanied by type II respiratory failure.
- •Patients who cannot understand and sign an informed consent form.
- •Patients with mental illness, pregnant women, and other special populations.
Outcomes
Primary Outcomes
incidence of composite event (cardiovascular mortality, unplanned HF hospitalization, emergency HF intervention)
Time Frame: 2 years
Cardiovascular disease death, heart failure readmission and emergency HF intervention are three endpoint events, with either occurring as the primary endpoint
Secondary Outcomes
- all-cause mortality(2 years)