The effects of memantine versus placebo on visual functions after scleral buckling for regmatogenous retinal detachment (RRD)

Phase 2

Active, not recruiting

• Conditions: patients with rhegmatogenus retinal detachment undergoing scleral buckeling surgery; Eye - Diseases / disorders of the eye

• Registration Number: ACTRN12609000111279
• Lead Sponsor: Tehran University of Medical sciences

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2009-02-18
• Last Update Posted: 13 January 2020

Recruitment & Eligibility

• Status: Active, not recruiting
• Sex: All
• Target Recruitment: 60

Inclusion Criteria

Macula off rhegmatogenus retinal detachment (RRD)
Duration<4 weeks
Proliferative vitreoretinopathy (PVR) A ;B
Visual acuity (V/A) < 20/200

Exclusion Criteria

Usage of digoxin and dextrometorphan (interacting with memantine)
Pregnancy an nursing
Renal disease
Failure of surgery
Longstanding retinal detachment (RD)
Other macular pathology

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Any change in visual acuity, testing by Early Treatment Diabetic Retinopathy Study (ETDRS) chart in LogMAR (Logarithmic value for Minimum Angle of Resolution)[Baseline, then on months 1, months 3]

Secondary Outcome Measures

Name	Time	Method
Any change in central macular thickness measured by optical coherence tomography (OCT)[Baseline, 3 months];Amplitudes of P waves in central macula measured by performing multifocal electroretinography (mERG) developed by Metrovision[3 months after operation];Contast sensitivity measurement in 4.8, 7.5, 12, & 15 cycle per degree measured by B-VATII Mentor[Baseline, 3 months]