Effect of two commonly used intravenous fluids (Ringers lactate and tetrastarch) on postoperative kidney functio
Not Applicable
Completed
- Conditions
- Health Condition 1: - Health Condition 2: null- Adult patients scheduled for major orthopaedic surgery under general anaesthesia with anticipated blood loss greater than 200-300 ml will be included in the study.
- Registration Number
- CTRI/2016/07/007114
- Lead Sponsor
- niversity College of Medical Sciences and GTB Hospital
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 32
Inclusion Criteria
Adult patients scheduled for major orthopaedic surgery under general anaesthesia with anticipated blood loss > 200-300 ml will be included in the study.
Exclusion Criteria
Those <18 years or >65 years, body mass index <15 or >40 kg/m2, will not be included. Patients with preoperative renal dysfunction, receiving renal replacement therapy, transplanted kidney, significant dysrhythmia, cardiac failure, stroke, coronary heart disease with left ventricular ejection fraction <50%, or preoperative haemoglobin < 8 gm% will be excluded from the study.
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Early postoperative Acute Kidney Injury diagnosed by the levels of NGAL(Neutrophil gelatinise associated Lipocalcin) in urine.Timepoint: After completion of surgery and on first postoperative day.
- Secondary Outcome Measures
Name Time Method 1. Early postoperative AKI diagnosed as per conventionally used definitions formulated by the Kidney Disease Initiative: Global Outcomes (KDIGO) guidelines, using serum creatinine and/or urine output. <br/ ><br>2. Intraoperative haemodynamic stability: in terms of mean arterial pressure, cardiac index and stroke volume/SVV. <br/ ><br>Timepoint: 1. For early AKI: Serum creatinine will be done at 48 hours postoperatively. <br/ ><br>2. For intraoperative haemodynamic stability the stated variables will be recorded every 10 minutes intraoperatively till end of surgery.