Adenosine-induced Stress Dynamic Myocardial Perfusion Imaging With Dual-source CT
试验速览
- 阶段
- 4 期
- 状态
- 终止
- 入组人数
- 51
- 试验地点
- 2
- 主要终点
- Diagnostic accuracy of stress induced CT perfusion
研究概览
简要总结
This study was designed as a prospective multicenter trial to determine the accuracy of combined CT coronary angiography and perfusion imaging, specifically quantitative dynamic perfusion imaging in patients with suspicious coronary artery disease compared conventional coronary angiography and quantitative dynamic perfusion MRI as standard reference.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Diagnostic
- 盲法
- None
入排标准
- 年龄范围
- 40 Years 至 80 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Men and women patients, with age ranging 40-
- •Suspected coronary artery disease who are supposed to undergo invasive coronary angiography with appropriate clinical indications
- •Patients who are willing to sign the informed consent form
排除标准
- •Contraindication of CT Known allergy to iodinated contrast media or history of contrast-induced nephropathy Decreased renal function: elevated serum creatinine(>1.5mg/dl) Contraindication to beta-blockers Severe arrhythmia: arterial fibrillation or uncontrolled tachyarrhythmia, or advanced atrioventricular block (second or third degree heart block)
- •Contraindication of MRI Claustrophobia Metallic hazards Pacemaker implant eGFR<30 ml/min
- •Unstable or uncooperative patients
- •Limited life expectancy due to cancer or end-stage renal or liver disease
- •Evidence of severe symptomatic heart failure (NYHA Class III or IV)
- •Previous myocardial infarction, coronary artery intervention, coronary artery bypass surgery, or other cardiac surgery
研究组 & 干预措施
CT perfusion group
干预措施: Adenosine stress dynamic CT perfusion (Other)
结局指标
主要结局
Diagnostic accuracy of stress induced CT perfusion
时间窗: 10-30 days
Diagnostic accuracy of combined stress and rest dynamic CT perfusion and coronary angiography with dual x-ray sources in detection of hemodynamically significant stenosis of coronary artery compared with conventional coronary angiography and perfusion MRI in patients with suspicious coronary artery disease.
次要结局
未报告次要终点