Adenosine-induced Stress Dynamic Myocardial Perfusion Imaging With Dual-source CT

Yonsei University1 site in 1 country51 target enrollmentJanuary 30, 2012

ConditionsCoronary Artery Disease

Overview

Phase: Phase 4
Intervention: Not specified
Conditions: Coronary Artery Disease
Sponsor: Yonsei University
Enrollment: 51
Locations: 1
Primary Endpoint: Diagnostic accuracy of stress induced CT perfusion
Status: Terminated
Last Updated: 7 years ago

Overview Investigators Eligibility Criteria Outcomes Sites Similar Trials

Overview

Brief Summary

This study was designed as a prospective multicenter trial to determine the accuracy of combined CT coronary angiography and perfusion imaging, specifically quantitative dynamic perfusion imaging in patients with suspicious coronary artery disease compared conventional coronary angiography and quantitative dynamic perfusion MRI as standard reference.

Registry

clinicaltrials.gov

Start Date

January 30, 2012

End Date

July 11, 2016

Last Updated

7 years ago

Study Type

Interventional

Study Design

Single Group

Sex

All

Investigators

Sponsor

Yonsei University

Responsible Party

Sponsor

Eligibility Criteria

Inclusion Criteria

•Men and women patients, with age ranging 40-
•Suspected coronary artery disease who are supposed to undergo invasive coronary angiography with appropriate clinical indications
•Patients who are willing to sign the informed consent form

Exclusion Criteria

•Contraindication of CT Known allergy to iodinated contrast media or history of contrast-induced nephropathy Decreased renal function: elevated serum creatinine(\>1.5mg/dl) Contraindication to beta-blockers Severe arrhythmia: arterial fibrillation or uncontrolled tachyarrhythmia, or advanced atrioventricular block (second or third degree heart block)
•Contraindication of MRI Claustrophobia Metallic hazards Pacemaker implant eGFR\<30 ml/min
•Unstable or uncooperative patients
•Limited life expectancy due to cancer or end-stage renal or liver disease
•Evidence of severe symptomatic heart failure (NYHA Class III or IV)
•Previous myocardial infarction, coronary artery intervention, coronary artery bypass surgery, or other cardiac surgery

Outcomes

Primary Outcomes

Diagnostic accuracy of stress induced CT perfusion

Time Frame: 10-30 days

Diagnostic accuracy of combined stress and rest dynamic CT perfusion and coronary angiography with dual x-ray sources in detection of hemodynamically significant stenosis of coronary artery compared with conventional coronary angiography and perfusion MRI in patients with suspicious coronary artery disease.