Adenosine-induced Stress Dynamic Myocardial Perfusion Imaging With Dual-source CT

Phase 4

Terminated

• Conditions: Coronary Artery Disease
• Interventions: Other: Adenosine stress dynamic CT perfusion

• Registration Number: NCT01680081
• Lead Sponsor: Yonsei University

Brief Summary

This study was designed as a prospective multicenter trial to determine the accuracy of combined CT coronary angiography and perfusion imaging, specifically quantitative dynamic perfusion imaging in patients with suspicious coronary artery disease compared conventional coronary angiography and quantitative dynamic perfusion MRI as standard reference.

Detailed Description

Not available

Basic Information
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Recruitment & Eligibility
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Study & Design
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Trial Locations

Study Timeline

• Study Start: 2012-01-30
• Study First Submitted: 2012-09-03
• Study First Submitted QC: 2012-09-05
• Study First Posted: 2012-09-06
• Primary Completion: 2016-07-11
• Study Completion: 2016-07-11
• Status Verified: 2019-01
• Last Update Submitted: 2019-01-18
• Last Update Posted: 2019-01-23

Recruitment & Eligibility

• Status: TERMINATED
• Sex: All
• Target Recruitment: 51

Inclusion Criteria

1. Men and women patients, with age ranging 40-80.
2. Suspected coronary artery disease who are supposed to undergo invasive coronary angiography with appropriate clinical indications
3. Patients who are willing to sign the informed consent form

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Exclusion Criteria

1. Contraindication of CT Known allergy to iodinated contrast media or history of contrast-induced nephropathy Decreased renal function: elevated serum creatinine(>1.5mg/dl) Contraindication to beta-blockers Severe arrhythmia: arterial fibrillation or uncontrolled tachyarrhythmia, or advanced atrioventricular block (second or third degree heart block)
2. Contraindication of MRI Claustrophobia Metallic hazards Pacemaker implant eGFR<30 ml/min
3. Unstable or uncooperative patients
4. Limited life expectancy due to cancer or end-stage renal or liver disease
5. Evidence of severe symptomatic heart failure (NYHA Class III or IV)
6. Previous myocardial infarction, coronary artery intervention, coronary artery bypass surgery, or other cardiac surgery

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Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Arm && Interventions

Group	Intervention	Description
CT perfusion group	Adenosine stress dynamic CT perfusion	-

Primary Outcome Measures

Name	Time	Method
Diagnostic accuracy of stress induced CT perfusion	10-30 days	Diagnostic accuracy of combined stress and rest dynamic CT perfusion and coronary angiography with dual x-ray sources in detection of hemodynamically significant stenosis of coronary artery compared with conventional coronary angiography and perfusion MRI in patients with suspicious coronary artery disease.

Trial Locations

Locations (1)

Severance hospital; 🇰🇷 Seoul, Korea, Republic of