Multicenter Diagnostic Performance of Dynamic CT Perfusion for Functional Assessment of Coronary Artery Disease
试验速览
- 阶段
- 不适用
- 入组人数
- 240
- 试验地点
- 1
- 主要终点
- Accuracy of myocardial perfusion obtained from dynamic cardiac CT perfusion imaging for detecting functionally significant coronary artery stenosis
研究概览
简要总结
The objective of this multicenter study is to evaluate the diagnostic accuracy of dynamic cardiac CT perfusion (CTP) imaging for non-invasive functional assessment of coronary artery disease (CAD). The proposed CTP technique allows concomitant assessment of two imaging-derived cardiac biomarkers including fractional flow reserve (FFR) and myocardial perfusion from a single dynamic imaging sequence, which facilities simultaneous evaluation of the hemodynamics in epicardial coronary arteries and coronary microcirculation in patients with CAD. The CTP results will be compared with invasive coronary angiography / FFR assessment and non-invasive cardiac magnetic resonance imaging (CMR) / radionuclide perfusion assessment.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Only
- 时间视角
- Prospective
入排标准
- 年龄范围
- 30 Years 至 80 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- 未提供
排除标准
- 未提供
结局指标
主要结局
Accuracy of myocardial perfusion obtained from dynamic cardiac CT perfusion imaging for detecting functionally significant coronary artery stenosis
时间窗: Within 4 weeks prior to invasive cardiac catheterization
Comparison with invasive coronary angiography and FFR assessment
Comparison of diagnostic accuracy for functional CAD assessment between dynamic CT perfusion and static CT perfusion
时间窗: Within 4 weeks prior to invasive cardiac catheterization
Comparison in patients with multi-vessel CAD where balanced ischemia is expected
Accuracy of combined myocardial perfusion and FFR measurement obtained from dynamic cardiac CT perfusion imaging for detecting functionally significant coronary artery stenosis
时间窗: Within 4 weeks prior to invasive cardiac catheterization
Comparison with invasive coronary angiography and FFR assessment
Comparison of diagnostic accuracy for functional CAD assessment between dynamic CT perfusion and CT-FFR (based on computational fluid dynamics simulation)
时间窗: Within 4 weeks prior to invasive cardiac catheterization
Comparison in patients with dense coronary calcification
Accuracy of FFR obtained from dynamic cardiac CT perfusion imaging for detecting functionally significant coronary artery stenosis
时间窗: Within 4 weeks prior to invasive cardiac catheterization
Comparison with invasive coronary angiography and FFR assessment
次要结局
- Comparison of diagnostic accuracy for functional CAD assessment between dynamic CT perfusion and other non-CT perfusion imaging techniques(Within 4 weeks of the acquisition of non-CT perfusion imaging)
- Comparison of diagnostic accuracy of dynamic CT perfusion for functional CAD assessment between male and female patients(Within 4 weeks prior to invasive cardiac catheterization)
研究者
Aaron So
Scientist
Lawson Health Research Institute