NCT00177060终止1 期
Topical Hydromorphone for Wound Healing
Hordinsky, Maria K., MD2 个研究点 分布在 1 个国家目标入组 50 人开始时间: 2003年10月1日最近更新:
适应症
相关药物
试验速览
- 阶段
- 1 期
- 状态
- 终止
- 发起方
- 入组人数
- 50
- 试验地点
- 2
- 主要终点
- Healing rates and microvessel density will be compared statistically for the control-ointment versus hydromorphone-ointment subjects.
研究概览
简要总结
The hypothesis is that topical opioids will hasten wound healing in humans.
详细描述
This is based on our published data that morphine is a powerful stimulant of angiogenesis and our preclinical study of wounds in rats which demonstrate that topical opioids (morphine, hydromorphone and fentanyl) hasten healing of punch biopsy wounds. This study will focus on hydromorphone which was more powerful than morphine as a wound-healer in the rat study.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Single Group
- 主要目的
- Treatment
- 盲法
- Single
入排标准
- 年龄范围
- 18 Years 至 65 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Self-identified as normal, healthy volunteers age 18-65.
排除标准
- •Known bleeding disorder.
结局指标
主要结局
Healing rates and microvessel density will be compared statistically for the control-ointment versus hydromorphone-ointment subjects.
次要结局
未报告次要终点
研究者
研究点 (2)
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