Topical Hydromorphone for Wound Healing

Phase 1

Terminated

• Conditions: Wound Healing

• Registration Number: NCT00177060
• Lead Sponsor: Hordinsky, Maria K., MD

Brief Summary

The hypothesis is that topical opioids will hasten wound healing in humans.

Detailed Description

This is based on our published data that morphine is a powerful stimulant of angiogenesis and our preclinical study of wounds in rats which demonstrate that topical opioids (morphine, hydromorphone and fentanyl) hasten healing of punch biopsy wounds. This study will focus on hydromorphone which was more powerful than morphine as a wound-healer in the rat study.

Study Timeline

• Study Start: 2003-10
• Study First Submitted: 2005-09-13
• Study First Submitted QC: 2005-09-13
• Study First Posted: 2005-09-15
• Study Completion: 2007-05
• Status Verified: 2010-02
• Last Update Submitted: 2010-02-26
• Last Update Posted: 2010-03-01

Recruitment & Eligibility

• Status: TERMINATED
• Sex: All
• Target Recruitment: 50

Inclusion Criteria

• Self-identified as normal, healthy volunteers age 18-65.

Exclusion Criteria

• Known bleeding disorder.

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Primary Outcome Measures

Name	Time	Method
Healing rates and microvessel density will be compared statistically for the control-ointment versus hydromorphone-ointment subjects.

Trial Locations

Locations (1)

University of Minnesota; 🇺🇸 Minneapolis, Minnesota, United States