The Effect of Menstrual Cycle Phase and Protein Dose on Muscle Protein Synthesis in Response to Exercise in Young Females
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 28
- 试验地点
- 1
- 主要终点
- Muscle protein synthesis
研究概览
简要总结
Adaptation to resistance exercise requires maximal rates of muscle protein synthesis, which can be achieved with post-exercise ingestion of ~20g of protein. These recommendations are based on studies in males and responses in females may vary.
Muscle recovery is related to the ability to build new muscle protein from amino acids (muscle protein synthesis). This response is thought to be impacted in females by hormones that fluctuate across different phases of the menstrual cycle. However, the effect of menstrual cycle phase on muscle protein synthesis is not known.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Basic Science
- 盲法
- Triple (Participant, Investigator, Outcomes Assessor)
入排标准
- 年龄范围
- 18 Years 至 40 Years（Adult）
- 性别
- Female
- 接受健康志愿者
- 是
入选标准
- •BMI between 18 and 30
- •Recreationally active
- •Regular menstrual cycle
排除标准
- •Metabolic disease
- •Any motor disorder
- •Use of over-the-counter pharmaceuticals, during the study.
- •Pomegranate, milk or lidocaine allergy
- •Taken contraceptives in the past 3 months
- •Irregular menstrual cycle (less than 9 cycles per year and a length not between 21-35 days)
- •Post-menopausal women
- •Pregnancy and lactation
研究组 & 干预措施
Protein dose 1 and early
干预措施: Dose of protein (Dietary Supplement)
Protein dose 1 and early
干预措施: Menstrual cycle phase (Other)
Protein dose 1 and late
干预措施: Dose of protein (Dietary Supplement)
Protein dose 1 and late
干预措施: Menstrual cycle phase (Other)
Protein dose 2 and early
干预措施: Dose of protein (Dietary Supplement)
Protein dose 2 and early
干预措施: Menstrual cycle phase (Other)
Protein dose 2 and late
干预措施: Dose of protein (Dietary Supplement)
Protein dose 2 and late
干预措施: Menstrual cycle phase (Other)
Protein dose 3 and early
干预措施: Dose of protein (Dietary Supplement)
Protein dose 3 and early
干预措施: Menstrual cycle phase (Other)
Protein dose 3 and late
干预措施: Dose of protein (Dietary Supplement)
Protein dose 3 and late
干预措施: Menstrual cycle phase (Other)
结局指标
主要结局
Muscle protein synthesis
时间窗: 7.5 hours
The rate of synthesis of new muscle protein
次要结局
- Sex hormone concentrations(5 minutes)
- Plasma amino acid kinetics(7.5 hours)
- Serum insulin concentrations(7.5 hours)
- Blood flow(7.5 hours)
- Gene expression(7.5 hours)
- Blood glucose(7.5 hours)