Comparison of Single-Dose Versus Three-Day Antibiotic Prophylaxis in Lower Urinary Tract Endourological Procedures: A Randomized Controlled Trial
Overview
- Phase
- Not Applicable
- Status
- Not yet recruiting
- Sponsor
- AIIMS Bhubaneswar
- Enrollment
- 200
Overview
Brief Summary
we plan To compare between 3 day postoperative dose of antibiotics vs single dose antibiotic in lower urinary tract surgeries. It is in practice to use 3 - 5 days of antibiotics for most of the urological procedures. Our goal is to find out the real world data and outcomes after using both the regimens. We will be including people undergoing Lower urinary tract surgeries with negative urine cultures within one week prior to surgery. we will use cefuroxime as antibiotic prophylaxis for all these patients as per institutional protocol. we will get done urine culture on day 3, and follow up the patient till 30 days of postoperative period to look for any symptomatic UTI. study duration would be around 18 months. we willl use computer based block randomization.
Study Design
- Study Type
- Interventional
- Allocation
- Randomized
- Masking
- None
Eligibility Criteria
- Ages
- 18.00 Year(s) to 90.00 Year(s) (—)
- Sex
- All
Inclusion Criteria
- •Undergoing elective TURP, TURBT, OIU, BNI, or CLT Preoperative sterile urine culture (within 7 days prior to surgery) Willing and able to provide written informed consent.
Exclusion Criteria
- •Evidence of preoperative UTI or positive urine culture
- •Immunocompromised status (e.g., HIV with CD4 <200, post-transplant, on immunosuppressants)
- •Chronic kidney disease (Stage IV or above)
- •Known allergy to cefuroxime or beta-lactam antibiotics
- •Patients requiring intraoperative or postoperative antibiotic escalation for other complications.
Investigators
Srujan S Dharap
AIIMS Bhubaneswar