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Clinical Trials/NCT07616882
NCT07616882Not yet recruitingPhase 2

Comparison of Hemodynamic Effects of Fractionated Dose Versus Bolus Dose of Hyperbaric Bupivacaine (0.5%) in Spinal Anesthesia for Lower Limb Surgery

Liaquat National Hospital & Medical College1 site in 1 country100 target enrollmentStarted: April 1, 2027Last updated:
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Trial Snapshot

Phase
Phase 2
Status
Not yet recruiting
Enrollment
100
Locations
1
Study OverviewStudy DesignEligibility CriteriaInvestigatorsSitesRecords & IdentifiersSimilar Trials

Study Overview

Brief Summary

To assess hemodynamic changes with hyperbaric bupivacaine with spinal anesthesia

Detailed Description

Assesment of hemodynamic changes like heart rate and blood pressure with hyperbaric bupivacaine in spinal anesthesia when given in fractionanted versus bolus dose manner

Study Design

Study Type
Interventional
Allocation
Randomized
Intervention Model
Crossover
Primary Purpose
Prevention
Masking
Double (Participant, Investigator)

Eligibility Criteria

Ages
18 Years to 60 Years (Adult)
Sex
All
Accepts Healthy Volunteers
No

Inclusion Criteria

  • •ASA I and II
  • •Adults 18 to 60 years of age of either gender
  • •height from 160 to 182cm and BMI from 15 to 29.9kg/m2

Exclusion Criteria

  • •ASA III and IV
  • •Refusal of consent
  • •any known renal, hepatic, cardiac or cerebrovascular disease
  • •hypersensitivity to local anaesthetics drug
  • •spinal deformity or any contra indications to spinal anesthesia

Investigators

Sponsor Class
Other
Responsible Party
Principal Investigator
Principal Investigator

Usama Bhurgri

Principal Investigator

Liaquat National Hospital & Medical College

Study Sites (1)

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