Gingival Crevicular Fluid and Serum Levels of Hepcidin, IL-6 and IL-10 in Periodontal Health and Disease
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 90
- 试验地点
- 1
- 主要终点
- Hepcidin levels
研究概览
简要总结
Periodontal disease refers to inflammatory disease of the periodontium caused by the host and/or pathogenic microorganisms. Anti-inflammatory and pro-inflammatory cytokines play a role in the periodontal inflammation process. The aim of this study was to evaluate the levels of hepcidin, interleukin (IL)-6, and IL-10 levels in gingival crevicular fluid (GCF) and in serum samples obtained from individuals with periodontal inflammation.
详细描述
The study included 90 individuals, who were divided into three groups: periodontally healthy (PH) (n=30); gingivitis (G) (n=30); and chronic periodontitis (CP) (n=30). GCF and serum samples were obtained from each individual, and samples were evaluated using ELISA. Statistical evaluation of the data was performed using the SPSS packet data program.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Cross Sectional
入排标准
- 年龄范围
- 32 Years 至 52 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Systematically healthy patients. Patients who did not receive any medication or periodontal treatment within the previous 6 months
排除标准
- •Individuals who smoked and women who were pregnant and/or lactating were excluded from the study
结局指标
主要结局
Hepcidin levels
时间窗: 1 year
Change in inflammatory phases
次要结局
- IL-10 levels(1 year)
- IL-6 levels(1 year)
研究者
ÇİĞDEM COŞKUN TÜRER
clinical associate professor, DDS, PhD
Bulent Ecevit University