Hepcidin Levels in Periodontal Health and Disease
- Conditions
- Periodontal Diseases
- Registration Number
- NCT03789565
- Lead Sponsor
- Bulent Ecevit University
- Brief Summary
Periodontal disease refers to inflammatory disease of the periodontium caused by the host and/or pathogenic microorganisms. Anti-inflammatory and pro-inflammatory cytokines play a role in the periodontal inflammation process. The aim of this study was to evaluate the levels of hepcidin, interleukin (IL)-6, and IL-10 levels in gingival crevicular fluid (GCF) and in serum samples obtained from individuals with periodontal inflammation.
- Detailed Description
The study included 90 individuals, who were divided into three groups: periodontally healthy (PH) (n=30); gingivitis (G) (n=30); and chronic periodontitis (CP) (n=30). GCF and serum samples were obtained from each individual, and samples were evaluated using ELISA. Statistical evaluation of the data was performed using the SPSS packet data program.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 90
- Systematically healthy patients. Patients who did not receive any medication or periodontal treatment within the previous 6 months
- Individuals who smoked and women who were pregnant and/or lactating were excluded from the study
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Hepcidin levels 1 year Change in inflammatory phases
- Secondary Outcome Measures
Name Time Method IL-10 levels 1 year Change in inflammatory phases
IL-6 levels 1 year Change in inflammatory phases
Trial Locations
- Locations (1)
Çiğdem Coşkun Türer
🇹🇷Zonguldak, Turkey
Çiğdem Coşkun Türer🇹🇷Zonguldak, Turkey