The effects of exercise on hunger, antropyloroduodenal motility, and gut hormones in healthy male volunteers

Christine Feinle-Bisset0 个研究点目标入组 16 人开始时间: 2013年3月14日最近更新: 2020年1月13日

适应症

试验速览

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•Sixteen (BMI 19-25 kg/m2) healthy subjects, aged between 18 - 35 years, will be recruited. All subjects will be required to be weight-stable (i.e. < 5 % fluctuation in their body weight) at study entry, as determined by their self-reported weight in the preceding 3 months, and will be required to maintain their normal physical activity over the course of the study.

•Each subject will be questioned prior to the study to exclude:
•-significant GI symptoms, disease or surgery
•-use of prescribed or non-prescribed medications (including vitamins and herbal supplements) which may affect energy metabolism, GI function, body weight or appetite (e.g. domperidone and cisapride, anticholinergic drugs (eg atropine), metoclopramide, erythromycin, hyoscine, orlistat, green tea extracts, Astragalus, St Johns Wort etc.)
•-lactose intolerance or other food allergy(s)
•-current gallbladder or pancreatic disease
•-diabetes mellitus
•-cardiovascular or respiratory diseases
•-any other illnesses as assessed by the investigator (including chronic illnesses not explicitly listed above)
•-high performance athletes
•-current intake of > 2 standard drinks on > 5 days per week
•-current smokers of cigarettes/cigars/marijuana
•-current intake of any illicit substance
•-restrained eaters (score > 12 on the three factor eating questionnaire)
•-experience of claustrophobia in confined spaces
•-inability to tolerate nasoduodenal tube
•-inability to comprehend study protocol

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