临床试验/NCT03675100

NCT03675100已完成不适用

Expression of Neurotrophic Factors, Tight Junction Proteins, and Cytokines According to the Irritable Bowel Syndrome Subtype and Sex

Seoul National University Bundang Hospital2 个研究点分布在 2 个国家目标入组 100 人开始时间: 2009年6月最近更新: 2020年3月24日

适应症

试验速览

阶段: 不适用
状态: 已完成
发起方: Seoul National University Bundang Hospital
入组人数: 100
试验地点: 2
主要终点: NGF, GDNF, and TRPV-1 mRNA expression of colonic mucosa

研究概览研究设计入排标准结局指标研究者研究点记录与标识符相似试验

研究概览

简要总结

To evaluate the role of neurotrophic factors (NGF, GDNF, TRPV-1), to quantity tight junction proteins (ZO-1, occludin, claudin) and cytokines (IL-8, TNF-a, IL-1b) in the colonic mucosa of IBS patients and also clarify sex differences in the pathophysiology of IBS.

研究设计

研究类型: Interventional
分配方式: Non Randomized
干预模型: Parallel
主要目的: Diagnostic
盲法: None

入排标准

年龄范围: 18 Years 至 80 Years（Adult, Older Adult）
性别: All
接受健康志愿者: 是

入选标准

•Control group Those who were between 18 and 80 years old and did not have any abnormalities in colonoscopy
•Irritable bowel syndrome group Patients who diagnosed as irritable bowel syndrome according to the ROME III criteria

排除标准

•history of IBD
•abdominal operation
•severe systemic disease
•malignancy,

结局指标

主要结局

NGF, GDNF, and TRPV-1 mRNA expression of colonic mucosa

时间窗: up to 24 weeks

real-time qPCR

次要结局

ZO-1, Occludin, and Claudin mRNA expression of colonic mucosa(up to 24 weeks)
IL-8, TNF-a, and IL-1b mRNA expression of colonic mucosa(up to 24 weeks)

研究者

发起方

Seoul National University Bundang Hospital

申办方类型

Other

责任方

Principal Investigator

主要研究者

Nayoung Kim

Professor

Seoul National University Bundang Hospital

研究点 (2)

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