Expression of Neurotrophic Factors, Tight Junction Proteins, and Cytokines According to the Irritable Bowel Syndrome Subtype and Sex
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 100
- 试验地点
- 1
- 主要终点
- NGF, GDNF, and TRPV-1 mRNA expression of colonic mucosa
研究概览
简要总结
To evaluate the role of neurotrophic factors (NGF, GDNF, TRPV-1), to quantity tight junction proteins (ZO-1, occludin, claudin) and cytokines (IL-8, TNF-a, IL-1b) in the colonic mucosa of IBS patients and also clarify sex differences in the pathophysiology of IBS.
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Parallel
- 主要目的
- Diagnostic
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 80 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Control group Those who were between 18 and 80 years old and did not have any abnormalities in colonoscopy
- •Irritable bowel syndrome group Patients who diagnosed as irritable bowel syndrome according to the ROME III criteria
排除标准
- •history of IBD
- •abdominal operation
- •severe systemic disease
- •malignancy,
研究组 & 干预措施
IBS group
Patients who were diagnosed with IBS according to the ROME III criteria. Colonoscopic mucosal biopsy was undertaken for every subject.
干预措施: colonoscopic mucosal biopsy (Procedure)
Control group
Healthy participants who have no gastrointestinal symptoms and no colonoscopic abnormality. Colonoscopic mucosal biopsy was undertaken for every subject.
干预措施: colonoscopic mucosal biopsy (Procedure)
结局指标
主要结局
NGF, GDNF, and TRPV-1 mRNA expression of colonic mucosa
时间窗: up to 24 weeks
real-time qPCR
次要结局
- ZO-1, Occludin, and Claudin mRNA expression of colonic mucosa(up to 24 weeks)
- IL-8, TNF-a, and IL-1b mRNA expression of colonic mucosa(up to 24 weeks)
研究者
Nayoung Kim
Professor
Seoul National University Bundang Hospital