Evaluation of Manasa Bhava and Rasa Dhatu Dushthi in the etiopathogenesis of Akalaja Palitya (Premature Canities) and comparative efficacy of Nimba Beeja Tail and Madhuka Tail with Brahma Rasayana in its management.
Phase 3
- Conditions
- Health Condition 1: L671- Variations in hair color
- Registration Number
- CTRI/2024/03/063872
- Lead Sponsor
- All India Institute of Ayurveda
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- ot Yet Recruiting
- Sex
- Not specified
- Target Recruitment
- 0
Inclusion Criteria
Diagnosed cases of Akalaja Palitya (Premature Canities) within the age group of 16-30 years,
irrespective of their gender, religion, economic status, chronicity of the disease, and who are willing
to provide informed consent for the study.
Exclusion Criteria
1. Any kind of fungal or other infection of the scalp.
2. Any major systemic disorder. (Except DM, HTN, CAD)
3. Pregnant and lactating ladies.
4. Other skin disorders like Psoriasis, Eczema, Leucoderma etc.
5. Patient is on chemotherapy or having history of chemotherapy.
6. Know case of Pernicious anaemia
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method To assess the etio-pathogenic role of Manasa Bhava (Krodha, Shoka) in <br/ ><br>Akalaja Palitya (premature canities) with the help of a validated proforma.Timepoint: Assessment will be done at the time of baseline.
- Secondary Outcome Measures
Name Time Method 1. To determine the association of Rasa Dhatu Dushti lakshana as described by Acharya Charaka <br/ ><br>in Akalaja Palitya (premature canities) with the help of a self-developed validated proforma. <br/ ><br>2. To assess the status of anxiety (HAM-A) in the study participants. <br/ ><br>3. To assess the nutritional status (Vit. B12, Vit. D3, Sr. Calcium, Sr. Ferritin, HB) of the study <br/ ><br>participants. <br/ ><br>4. To compare the effect of Nimba Beeja Tail (Pratimarsha Nasya) or Madhuka Tail <br/ ><br>(Pratimarsha Nasya) with Brahma Rasayana in Akalaja Patlitya patients in terms of changes <br/ ><br>in GSS score & signs & symptoms of Palitya after intervention of 90 days. <br/ ><br>5. To assess the status of Oxidative stress index (MDA, rGSH, SOD) in the study participants <br/ ><br>(Before & after treatment).Timepoint: Assessment of GSS score, signs & symptoms of Palitya & Oxidative stress index will be done at baseline & after 3 months.