High-frequency vs. Low-frequency vs. Sham DMPFC-rTMS for Bulimia and Anorexia Nervosa
- Conditions
- Bulimia NervosaAnorexia Nervosa
- Registration Number
- NCT02702167
- Lead Sponsor
- University Health Network, Toronto
- Brief Summary
This trial will compare the efficacy and tolerability of 10 Hz vs. 1 Hz vs. sham repetitive transcranial magnetic stimulation targeting the dorsomedial prefrontal cortex, delivered once daily over 30 days, in patients with a diagnosis of bulimia or anorexia nervosa binge-purge subtype. The trial will include structural and functional MRI, and behavioral measures obtained before, during, and after treatment.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- TERMINATED
- Sex
- All
- Target Recruitment
- 90
Not provided
Not provided
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Primary Outcome Measures
Name Time Method Weekly Binge/Purge Frequency on Eating Disorder Examination (EDE) Baseline, after each week of treatment, and 1, 4, 12, and 24 weeks post-treatment Outcome measured by a change in weekly binge and purge episodes from baseline to 2 weeks post-treatment. A 50% improvement in the score is considered a response to rTMS. A final score of 0 weekly binges and 0 weekly vomits is categorized as remission.
- Secondary Outcome Measures
Name Time Method Eating Disorder Inventory-3 Baseline, after each week of treatment, and 1, 4, 12, and 24 weeks post-treatment Eating Disorder Examination Questionnaire (EDE-Q) Baseline, after each week of treatment, and 1, 4, 12, and 24 weeks post-treatment
Related Research Topics
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Trial Locations
- Locations (1)
Toronto Western Hospital
🇨🇦Toronto, Ontario, Canada
Toronto Western Hospital🇨🇦Toronto, Ontario, Canada