Wheeze in preschool children: the predictive value of episodic viral wheeze and multiple-trigger wheeze in the development of childhood asthma.
- Conditions
- wheeze10006436
- Registration Number
- NL-OMON48853
- Lead Sponsor
- Amphia Ziekenhuis
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 171
The study population consists of 6- to 9-year-old children who were known for recurrent wheezing at the age of 1- to 4- years, treated by hospital-based paediatricians and included in the previous (WHEEP)study. Recurrent wheezing was defined as a minimum of 3 reported episodes in the year before inclusion, of which at least one must have been confirmed by a pediatrician. Children were then recruited from pediatric departments of ten general and academic hospitals in the Netherlands. During the 1-year (WHEEP)study period wheeze patterns were classified from patient diaries and compared to pediatrician assigned phenotypes.
No new exclusion criteria. All children who participated in the former study are eligible. As in the former study children of whom their parents do not understand the Dutch language are not eligible.
Study & Design
- Study Type
- Observational invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>The primary outcome measure is the predictive value of the preschool wheezing<br /><br>phenotype (diary based as wel as clinically based) in the development of<br /><br>childhood asthma.</p><br>
- Secondary Outcome Measures
Name Time Method <p>The sensitivity and specificity of the following asthma predictive scores in<br /><br>our cohort will be evaluated: the Asthma Predictive Index (API) and the<br /><br>Prevention and Incidence of Asthma and Mite Allergy risk score (PIAMA).<br /><br><br /><br>Another secondary outcome measure is the predictive value of viral upper<br /><br>respiratory tract infections at preschool age in the development of asthma. The<br /><br>results of nasal swabs, collected in the previous study, will be compared to<br /><br>asthma status at the age of 6 to 8 years.<br /><br>Moreover, we will study differences in microbiome at preschool age between<br /><br>children who develop childhood asthma and children who do not. In order to<br /><br>compare the microbiome at preschool age to the microbiome at the age of 6 to 8<br /><br>years, throat swabs will be collected. </p><br>