跳至主要内容
临床试验/NCT04710095
NCT04710095已完成不适用

Perceived Alcohol Reward Value and Risk: Neural Correlates and Treatment Effects

University of California, Los Angeles0 个研究点目标入组 60 人开始时间: 2015年11月13日最近更新:
适应症

试验速览

阶段
不适用
状态
已完成
入组人数
60
主要终点
Percent Heavy Drinking Days

研究概览

简要总结

The identification of mechanisms that underlie how people reduce or eliminate alcohol use is a critical public health issue. Understanding these mechanisms can inform how to effectively intervene with problem drinkers. Thus far it has been a challenge for the alcohol research field to find consistent empirical evidence in support of candidate mechanisms of behavior change. Scientific advancement in this area may be aided by longitudinal transdisciplinary research on the interplay between behavioral intervention, cognition, and brain activity to understand underlying processes of behavior change among heavy drinkers. This study employed a randomized 2-arm repeated measures design with a sample of non-treatment seeking adult heavy drinkers to examine changes in perceived reward value and risks of alcohol use as a mechanism of alcohol behavior change after a brief behavioral intervention. Participants were randomized to either a 1-session behavioral intervention or to an attention-matched control condition and immediately after completed an fMRI scan. The focus of this project is to examine if group differences in perceived alcohol reward value after the intervention mediates an intervention effect on reducing alcohol use in the 1 month following the intervention.

研究设计

研究类型
Interventional
分配方式
Randomized
干预模型
Parallel
主要目的
Treatment
盲法
None

入排标准

年龄范围
21 Years 至 —(Adult, Older Adult)
性别
All
接受健康志愿者

入选标准

  • engaged in regular heavy drinking, as indicated by consuming 5 or more drinks per occasion for men or 4 or more drinks per occasion for women at least 4 times in the month prior to enrollment
  • a score of ≥ 8 on the Alcohol Use Disorder Identification Test (AUDIT)

排除标准

  • under the age of 21
  • currently receiving treatment for alcohol problems, history of treatment in the 30 days before enrollment, or currently seeking treatment
  • a positive urine toxicology screen for any drug other than cannabis
  • a lifetime history of schizophrenia, bipolar disorder, or other psychotic disorder
  • serious alcohol withdrawal symptoms
  • history of epilepsy, seizures, or severe head trauma
  • non-removable ferromagnetic objects in body
  • claustrophobia

结局指标

主要结局

Percent Heavy Drinking Days

时间窗: 4 weeks post intervention

Percent heavy drinking days defined as 5+ drinks for men and 4+ for women according to self-reported Timeline Follow Back (TLFB) data

Neural Alcohol Cue Reactivity

时间窗: Single time point immediately post intervention

Neural alcohol cue reactivity as measured by whole brain activation to alcohol taste cue vs. water taste cue using functional magnetic resonance imaging (fMRI)

次要结局

未报告次要终点

研究者

申办方类型
Other
责任方
Principal Investigator
主要研究者

Lara Ray, PhD

Co-Principal Investigator

University of California, Los Angeles

相似试验

Perceived Alcohol Rewards and Risks Study | 临床试验