The Effect of Exercise and Metformin on Carotid Intima-media Thickness in Patients With Prediabetes
试验速览
- 阶段
- 不适用
- 发起方
- 入组人数
- 90
- 试验地点
- 2
- 主要终点
- Carotid ultrasound
研究概览
简要总结
The aim of this study is to evaluate whether there is a change in carotid intima media thickness with the application of guide-based exercise programs in individuals with prediabetes, and to evaluate whether there is a difference between the group in which exercise programs were applied and those who received only lifestyle change and metformin.
详细描述
The researchers think that the application of guide-based exercise programs in prediabetes patients will decrease the carotid intima-media thickness.The aim of this study is to evaluate whether there is a change in carotid intima media thickness with the application of guide-based exercise programs in individuals with prediabetes, and to evaluate whether there is a difference between the group in which exercise programs were applied and those who received only lifestyle change and metformin.
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 60 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Leading a sedentary life
- •Those who have sufficient motivation to participate in the exercise program (will be evaluated by a one-on-one interview by the researchers)
- •Have the same weight for 6 months before participating in the study (±2.5 kg)
- •Those diagnosed with prediabetes by oral glucose tolerance test and/or HbA1c measurement
排除标准
- •Serious medical condition (for example, advanced malignancy or major neurological, psychiatric or endocrine disease, respiratory failure, etc.) that would prevent the person from participating in exercise training.
- •Having cardiovascular disease
- •Being diabetic
- •Using metformin before participating in the study
- •Receiving hormone replacement therapy
- •Life expectancy less than 1 year
- •HIV positivity
- •Substance use
- •Functional dependency
- •Cognitive weakness
- •Those who have other diseases that will affect the results of the study (respiratory diseases, muscle diseases, etc.)
- •Those who use drugs or supplements that will affect the results of the study
结局指标
主要结局
Carotid ultrasound
时间窗: 12 weeks
milimeter size of carotid intima media thickness
次要结局
未报告次要终点