Inflammatory Biomarkers In Stroke - Discovery Phase
试验速览
- 阶段
- 不适用
- 状态
- 进行中（未招募）
- 发起方
- 入组人数
- 200
- 试验地点
- 1
- 主要终点
- Novel biomarkers of pneumonia
研究概览
简要总结
This study will look for new biomarkers of infection and evaluate current biomarkers of infection in stroke patients. Patients with acute stroke will be monitored with daily blood samples for seven days and by clinical examination to detect infections for 10 days.
详细描述
Rationale: Stroke is one of the leading causes of death globally, and infections after stroke contribute to a large part of the stroke-related mortality. The current study, which has a prospective, observational design, constitutes the second phase out of four in the Inflammatory Biomarkers In Stroke (IBIS) project, of which the overall goal is to enable early treatment of post-stroke infections.
Aim: To develop a combined clinical and molecular biological signature for early detection of pneumonia in patients with stroke.
Design: Prospective nested case control study
Methods:Patients (n=200) with acute stroke will be monitored with clinical examinations for ten days and by daily blood samples for seven days. When cases of pneumonia have been established, samples and examination results from days preceding overt pneumonia will be compared to samples from similar patients that did not develop pneumonia.
Outcome: Using proteomic and metabolomic methods, novel markers of upcoming pneumonia after stroke will be sought. Such laboratory markers will be combined with current biomarkers (such as C-reactive protein and procalcitonin) and data from clinical examinations, with the aim of constructing a biological signature that enables early detection of pneumonia.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Symptoms and radiology consistent with acute cerebral infarction or atraumatic intracerebral hemorrhage.
- •National Institutes of Health Stroke Scale (NIHSS) ≤5; mild stroke (n=25), NIHSS ≤10 and ≥ 6; moderate stroke (n=25) or NIHSS ≥ 11; severe stroke (n=150)
- •Onset of symptoms less than 48 hours before first study blood sampling.
排除标准
- •Symptoms and radiology consistent with acute cerebral infarction but full reversal of symptoms within 24 hours of onset. (i.e. transient ischemic attack, TIA)
- •Hemoglobin less than 90 g/l.
- •Ongoing inflammatory disease, such as rheumatoid arthritis or active inflammatory bowel disease.
- •Inability to undergo MRI scan (only patients with NIHSS ≤10 will be excluded by this criteria)
结局指标
主要结局
Novel biomarkers of pneumonia
时间窗: The day before pneumonia onset.
The study will analyze a broad expanse of potential biomarkers, including known markers of infection such as c-reactive protein, procalcitonin and increased respiratory frequency as well as novel markers that will be pursued using proteomic and metabolomic methods. Those that are significantly associated with upcoming pneumonia will be selected. Biomarkers will be evaluated by the area under the curve for the receiver operating characteristic (AUC-ROC).
A combined clinical and molecular biological signature for early detection of pneumonia
时间窗: The day before pneumonia onset.
By combining novel (found using proteomic and metabolomic methods) and current biomarkers (such as c-reactive protein, procalcitonin and increased respiratory frequency) with data from clinical examinations, a biological signature that enables early detection of pneumonia will be constructed.
次要结局
未报告次要终点
研究者
Jakob Ström
Jakob Ström, MD, PhD, resident of neurology and Associate Professor
Region Örebro County