Positivity Training: Effects of a Bias Modification Training on Emotion Processing in Major Depression and healthy Controls

Not Applicable

• Conditions: DSM-V: Major Depression; F32; Depressive episode

• Registration Number: DRKS00029756
• Lead Sponsor: Klinik für Psychiatrie, Psychotherapie und Psychosomatik., Uniklnik RWTH Aachen

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2022-08-16
• Last Update Posted: 19 August 2024

Recruitment & Eligibility

• Status: Pending
• Sex: All
• Target Recruitment: 240

Inclusion Criteria

Major Depression:
DSM-V: 32.0/1/2/4/5/8/9;
DSM-V: 33.0/1/2/4/5/9

Exclusion Criteria

Pregnancy, Symtoms of psychosis or mania. Substance dependency (apart from Nicotine). Neurological disorders and diseases affecting the brain: hypo- or hyperthyroidism, diabetes (HBA1c > 7,5, stroke).

Study & Design

• Study Type: interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Change in Amplitude (µV) of the Early Processing Negativity (EPN) derived from EEG in response to picture stimuli with posivie emotion valence from pre- to post intevention assessments.

Secondary Outcome Measures

Name	Time	Method
Prä/post intervention change in Late Positive Potential Evoked Response Potential Amplitude (µV) (LPP), EEG microstates derived from EEG, <br>Montgomery Asberg Rating Scale rating score (MADRS)<br>Hamilton Depresson Rating Scale rating score (HAMD)<br>Beck Depression Inventory questionnaire score (BDI-II)<br>State-Traint Anxiety Inventory questionnaire score (STAI)