Predictive value of Magnetic Resonance Imaging (MRI), positron emission tomography (PET), and microemboli detection for stroke

Completed

• Conditions: atherosclerotic plaques; hardening of the arteries; 10003216

• Registration Number: NL-OMON31611
• Lead Sponsor: Academisch Medisch Centrum

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 13 May 2024

Recruitment & Eligibility

• Status: Completed
• Sex: Not specified
• Target Recruitment: 278

Inclusion Criteria

Patients with neurological symptoms due to ischemia in the carotid artery territory and with a carotid stenosis between 30% and 69% as detected by US will be included (n<=263)
Patients with an asymptomatic carotid stenosis (detected by US) (n<=15)

Exclusion Criteria

-Patients with evident other cause of neurological symptoms than carotid stenosis.
-Patients that are already scheduled for carotid endarterectomy or stenting
-Patients that are already scheduled for an intervention that is associated with embolization.
-Severe co-morbidity, amaorosis Fugax, dementia, or pregnancy.
-Standard contra-indications for MRI (ferromagnetic implants such as pacemakers and other implanted electrical devices, metallic fragments in the eyes, surgical vessel clips, claustrophobia, documented allergy to contrast media etc).

Study & Design

• Study Type: Observational non invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>Primary endpoint is ipsilateral recurrent ischemic stroke alone. </p><br>

Secondary Outcome Measures

Name	Time	Method
<p>Secondary endpoints are the combined endpoint of ipsilateral ischemic stroke<br /><br>and ipsilateral TIA, and the combined endpoint of ipsilateral ischemic stroke,<br /><br>ipsilateral TIA, and ipsilateral silent infarct as detected on brain MRI.<br /><br>Another secondary endpoint is the influence of patient positioning in the MRI<br /><br>scanner on results of plaque morphology and composition analyses.</p><br>