Evaluation of the predictive value of Dynamic MRI in determining treatment response in perianal fistulizing Crohn*s disease before and after treatment with Infliximab

• Conditions: Crohn; inflammatory bowel disease; 10017969

• Registration Number: NL-OMON32206
• Lead Sponsor: Academisch Medisch Centrum

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 13 May 2024

Recruitment & Eligibility

• Status: Pending
• Sex: Not specified
• Target Recruitment: 33

Inclusion Criteria

proven Crohn*s disease by endoscopy and/or histopathology
draining perianal fistula

Exclusion Criteria

under 18 years of age
general contraindications to MRI (claustrophobia, pregnancy, renal insufficiency, pacemakers).

Study & Design

• Study Type: Observational invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>Predictive value of DCE-MRI before anti-TNF treatment and during treatment (6<br /><br>weeks) in predicting or identifying early response as compared to the PDAI<br /><br>after 6 weeks and 12 weeks.<br /><br>Predictive value of DCE-MRI after twelve weeks of anti-TNF treatment as<br /><br>compared to the PDAI after 1 year. </p><br>

Secondary Outcome Measures

Name	Time	Method
<p>DCE-MRI compared to the MRI-based score, CRP.</p><br>