May Covid-19 Impair Executive Functions? A Crossectional Study
Trial Snapshot
- Phase
- Not Applicable
- Status
- Completed
- Sponsor
- Enrollment
- 128
- Locations
- 1
- Primary Endpoint
- Neuropsychological test scores
Study Overview
Brief Summary
As it is evident that Covid-19 may have some impacts on cognition, the primary aim of this study is to investigate -if any- deficits of attention, working memory and executive functions after Covid-19.
Detailed Description
Since Covid-19 (Coronavirus Disease-2019) was declared as a pandemic by the World Health Organization (WHO) on December 31, 2019, it is still widespread and deadly. As an ongoing pandemic, it has led to a panic and then a controlled fear in societies. In many studies, neuropsychological deficits were observed in Covid-19 patients both during the illness and after recovery. A recent study found that impairment in cognitive functions continued after recovery of Covid-19, and it was associated with peripherical inflammatory markers, such as C-Reactive Protein (CRP). CRP, as a peripherical inflammatory marker, has been proven to be inversely related to serum levels of the brain-derived neurotrophic factor (BDNF), an important neurotrophin in the growth and differentiation of neurons. In this study, attention, working memory and executive functions of Covid-19 patients at post-covid period and its relation with the severity of the disease will be investigated.
Study Design
- Study Type
- Observational
- Observational Model
- Cohort
- Time Perspective
- Prospective
Eligibility Criteria
- Ages
- 18 Years to — (Adult, Older Adult)
- Sex
- All
- Accepts Healthy Volunteers
- Yes
Inclusion Criteria
- •Covid-19 patients:
- •Diagnosed as Covid-19 by RT-PCR at least 60 days but not more than 90 days ago
- •Asymptomatic at the moment
- •Not having any other general medical, neurological or psychiatric conditions except Covid-19 at the time of acute infection
- •Healthy subjects:
- •Not having any of Covid-19 symptoms at the testing time point
- •Not having any general medical, neurological or psychiatric condition
Exclusion Criteria
- •Covid-19 patients:
- •Diagnosed as Covid-19 by RT-PCR less than 60 days or more than 90 days ago
- •Having any symptom of acute phase of Covid-19
- •Having any other general medical, neurlogical or psychiatric contidions
- •Healthy subjects:
- •Having any of Covid-19 symptoms at the testing time point
- •Having any general medical, neurological or psychiatric condition
Outcomes
Primary Outcomes
Neuropsychological test scores
Time Frame: Up to 90 days
Neuropsychological test scores of Covid-19 patients in comparison with healthy control subjects
Secondary Outcomes
- Severity of the disease(Up to 90 days)
Investigators
Mehmet Diyaddin Güleken
Medical Doctor
Saglik Bilimleri Universitesi Gazi Yasargil Training and Research Hospital