Prompt Human Coronary Collateral Vasomotor Function Induced by Dynamic Physical Exercise

Not Applicable

Completed

• Conditions: Coronary Artery Disease
• Interventions: Other: dynamic physical exercise

• Registration Number: NCT00947050
• Lead Sponsor: Insel Gruppe AG, University Hospital Bern

Brief Summary

The purpose of this study in humans with stable coronary artery disease (CAD) treatable by PCI (percutaneous coronary intervention) is to evaluate if dynamic physical exercise leads to an instantaneous improvement of coronary collateral function.

Detailed Description

The existence of coronary collateral vessels and their benefit against cardiac events have been recognized for many years, but their functional capacity in response to physical exercise has partially remained elusive. Via endothelial shear stress, the fundamental stimulus for collateral development, exercise theoretically leads to collateral vasodilation and recruitment by an increase in heart rate and blood pressure during exercise. Moreover, the phenomenon of "walking through angina" indicates that collateral function and physical activity are related and their interaction is of clinical relevance.

The purpose of the present study in humans with stable coronary artery disease was to assess the instantaneous response of coronary collateral function to dynamic physical exercise.

Study Timeline

• Study Start: 2005-04
• Primary Completion: 2008-12
• Study Completion: 2009-03
• Study First Submitted: 2009-07-24
• Study First Submitted QC: 2009-07-24
• Study First Posted: 2009-07-27
• Status Verified: 2010-10
• Last Update Submitted: 2010-10-25
• Last Update Posted: 2010-10-26

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 30

Inclusion Criteria

• Age more than or 18 years old
• 1- to 3-vessel coronary artery disease (CAD)
• Stable angina pectoris
• At least 1 stenotic lesion suitable for PCI
• Negative Allen-test
• Written informed consent to participate in the study

Exclusion Criteria

• Patients admitted as emergencies
• Acute myocardial infarction
• Unstable CAD
• Q-wave myocardial infarction in the area undergoing CFI measurement
• CAD treated best by CABG
• Severe valve disease
• Pregnancy

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Arm && Interventions

Group	Intervention	Description
exercise first	dynamic physical exercise	ex first
rest first	dynamic physical exercise	rest first, cfi, exercise, cfi

Primary Outcome Measures

Name	Time	Method
Change of collateral flow index (CFI, no unit) during exercise (E) compared to CFI at rest (R).	6 minutes

Secondary Outcome Measures

Name	Time	Method
Correlation of collateral flow index change and maximal workload.	6 minutes

Trial Locations

Locations (1)

University Hospital Bern; 🇨🇭 Bern, Switzerland