Cardiorespiratory Fitness and the Apolipoprotein E (ApoE) Genotype and Its Interaction With Cognitive Functions and Cognitive Decline in Late-Middle-Aged Older Adults: A Prospective Study
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 159
- 试验地点
- 1
- 主要终点
- Changes in Inhibitory Performance: Stroop Task
研究概览
简要总结
The current research project aims to investigate the interaction of cardiorespiratory fitness (CRF) and the ApoE genotype with neurocognitive functions.
详细描述
The current research project aims to investigate the interaction of cardiorespiratory fitness (CRF) and the ApoE genotype with neurocognitive functions. The three main purposes of the current research project seek to achieve:
- An exploration of the associations of, as well as the interactions between, CRF assessed at the Baseline Stage, and the ApoE genotype, along with cognitive functions in cognitively healthy late-middle-aged older adults.
- The employing of an event-related potential (ERP) to investigate the associations between the baseline CRF, the ApoE genotype, and cognitive functions in cognitively healthy late-middle-aged older adults, as well as the potential underlying neuroelectrical mechanisms.
- An investigation of the interactions between the changes of CRFs assessed at the Baseline and the Follow-Up Stages and the ApoE genotype in relation to neurocognitive function, as well as the underlying neuroelectrical mechanisms, in cognitively healthy late-middle-aged older adults.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 50 Years 至 70 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •right handed
- •no history of cardiorespiratory disease
- •normal or corrected-to-normal vision based on the 20/20 standard
- •no risk of performing physical activities, as measured by the Physical Activity Readiness Questionnaire
排除标准
- •the scores of Mini-Mental Status Examination (MMSE) < 25 and cognitively intact upon study entry
- •history of psychiatric or neurological diseases
- •color-blindness
结局指标
主要结局
Changes in Inhibitory Performance: Stroop Task
时间窗: 30 minutes each at the Baseline and the Follow-Up visit at Month 18
Inhibitory performance was assessed using the computerized Stroop task at the Baseline and at the Follow-Up assessments. The difference in response time (RT) between the Baseline and the Follow-Up Stages was calculated as the index of the inhibitory performance.
Changes in Neuroelectrical Activities
时间窗: 30 minutes each at the Baseline and the Follow-Up visit at Month 18
The neuroelectrical activities (P3 component) during the Stroop task were recorded and analyzed using the Neuroscan system. The difference in P3 amplitudes of incongruent trials between the Baseline and the Follow-Up Stages was calculated as the index of the neuroelectrical index.
次要结局
- Number of Participants for Whom ApoE Genotype Was Determined(5 minutes at the Baseline Stage.)
- Physical Fitness Measurements: Changes in Aerobic Fitness(30 minutes each at the Baseline and the Follow-Up visit at Month 18)
研究者
Yu-Kai Chang
Professor
National Taiwan Normal University