Study of Bronchiectasis and Associated Cardiovascular Comorbidities
- Conditions
- Bronchiectasis
- Interventions
- Device: Echocardiography
- Registration Number
- NCT05783869
- Lead Sponsor
- Assiut University
- Brief Summary
Effect of cardiovascular comorbidities on disease severity and quality of life in Patients with acute exacerbation of non-cystic fibrosis bronchiectasis
- Detailed Description
The study will include patients with bronchiectasis, and in an attempt to correlate the effect and burden of cardiovascular comorbidities in those patients, we will study the quality of life in those patients in comparison to the control group ( patients with bronchiectasis and without any other comorbidities) using SF-36 quality of life questionnaire. We will also study the inflammatory markers in both groups using D-dimer, BNP, and CRP and correlate them with the frequency of hospital admission, the severity of symptoms, and the general health state.
Recruitment & Eligibility
- Status
- RECRUITING
- Sex
- All
- Target Recruitment
- 30
• Any Patients with Bronchiectasis had no comorbidities other than cardiovascular comorbidities during the study period.
- Any Patients who refuse to participate in the study.
- Any other comorbidity or end-organ failure may affect the study's result.
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Arm && Interventions
Group Intervention Description Patients with bronchiectasis and without cardiovascular comorbidities Echocardiography Patients with Bronchiectasis had no comorbidities. Patient with bronchiectasis and cardiovascular comorbidities Echocardiography Patients with Bronchiectasis had no comorbidities other than cardiovascular comorbidities during the study period.
- Primary Outcome Measures
Name Time Method assessment of BNP (Brain natriuretic peptide) pg/ml levels in patients with bronchiectasis and cardiovascular comorbidities. March 2023 to September 2023 Serum BNP (Brain natriuretic peptide) pg/ml will be compared in both groups.
Assessment of Quality of life in patients and control groups using The Short Form (36) Health Survey (SF-36) March 2023 to September 2023 The Short Form (36) Health Survey will be performed in both groups. The SF-36 consists of eight scaled scores, which are the weighted sums of the questions in their section. Each scale is directly transformed into a 0-100 scale on the assumption that each question carries equal weight. The lower the score the more disability. The higher the score the less disability i.e., a score of zero is equivalent to maximum disability and a score of 100 is equivalent to no disability.
- Secondary Outcome Measures
Name Time Method Hospitalization frequency in patient group compared to control group. March 2023 to September 2023 Number of hospital admission in the last year will be compared in both groups.
Trial Locations
- Locations (1)
Assiut unviresty - Faculty of Medicine
🇪🇬Assiut, Egypt