Association between cardiovascular risk and moderate-severe obstructive sleep apnea in Chile

Not Applicable

• Conditions: Obstructive sleep apnea; Nervous System Diseases; Sleep apnoea

• Registration Number: ISRCTN62293645
• Lead Sponsor: Clinica Las Condes

Brief Summary

2021 Interim results article in https://www.ncbi.nlm.nih.gov/pubmed/32232718 oximetric parameter sub-analysis results (added 03/04/2020) 2023 Interim results article in https://pubmed.ncbi.nlm.nih.gov/37568362/ (added 04/09/2023) 2021 Interim results article in https://pubmed.ncbi.nlm.nih.gov/34217682/ (added 04/09/2023) 2021 Interim results article in https://pubmed.ncbi.nlm.nih.gov/33394326/ (added 04/09/2023) 2020 Interim results article in https://pubmed.ncbi.nlm.nih.gov/32780496/ (added 04/09/2023) 2020 Interim results article in https://pubmed.ncbi.nlm.nih.gov/32771926/ (added 04/09/2023)

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2019-07-24
• Last Update Posted: 18 September 2023
• Study Completion: 2035-12-31

Recruitment & Eligibility

• Status: Ongoing
• Sex: All
• Target Recruitment: 3000

Inclusion Criteria

1. Participants aged >18 years
2. Referred for the sleep study because of the clinical suspicion of OSA (snoring symptoms, apneas observed by bed partner or excessive daytime sleepiness or major cardiovascular comorbidities)

Exclusion Criteria

1. Participants with other sleep disorders such as periodic limb movements of sleep (PLMS), NREM and arousal, REM and hypoxia, arousal and poor sleep
2. Participants who refuse to sign the consent form

Study & Design

• Study Type: Observational
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
1. All-cause mortality measured through a review of the national register database (https://www.registrocivil.cl) at 3, 5 and 10 years<br>2. Cardiovascular mortality measured through a review of the national register database (https://www.registrocivil.cl) at 3, 5 and 10 years

Secondary Outcome Measures

Name	Time	Method
1. New onset of hypertension measured by either medical record or telephone consultation at 5 and 10 years<br>2. New onset of T2DM measured by either medical record or telephone consultation at 5 and 10 years<br>3. New onset of CHD measured by either medical record or telephone consultation at 5 and 10 years<br>4. New onset of atrial fibrillation measured by either medical record or telephone consultation at 5 and 10 years