Evaluation of Fluid Responsiveness With Recruitment Maneuver After Sternotomy in Coronary Artery Bypass Surgery

Recruiting

• Conditions: Fluid Therapy; Coronary Artery Bypass Surgery Patients; Lung Recruitment Maneuver

• Registration Number: NCT06249568
• Lead Sponsor: Ankara City Hospital Bilkent

Brief Summary

Assuming that the basic reliability of dynamic indices will increase with the application of functional hemodynamic tests after sternotomy and protective lung ventilation in patients undergoing elective coronary artery bypass surgery, it is useful to predict fluid responsiveness after sternotomy in coronary artery bypass surgery patients ventilated with 6 ml/kg PBW (ideal body weight). We aimed to reveal the sensitivity and specificity of PPV and SVV changes by applying a lung opening maneuver.

Detailed Description

In order to evaluate the fluid deficit in patients undergoing coronary artery bypass surgery, researchers will measure stroke volume index, cardiac index and mean arterial pressure while the patients are in the lima position.

Then researchers will perform a lung opening maneuver (30mmHg for 30 seconds) and measure again.

researchers will measure again after the values return to normal. researchers will give patients balanced fluid at 3ml/kg and record their values.

Can researchers predict fluid response with lung opening maneuver?

Study Timeline

• Study Start: 2023-06-01
• Study First Submitted: 2024-01-13
• Study First Submitted QC: 2024-01-31
• Study First Posted: 2024-02-08
• Status Verified: 2024-07
• Last Update Submitted: 2024-07-15
• Last Update Posted: 2024-07-16
• Primary Completion: 2024-08-02
• Study Completion: 2024-08-20

Recruitment & Eligibility

• Status: RECRUITING
• Sex: All
• Target Recruitment: 45

Inclusion Criteria

• 1-ASA2-3 patients between the ages of 18-80 who will undergo elective coronary bypass surgery under general anesthesia

Exclusion Criteria

• 1. Be younger than 18 years old, be over 80 years old
• 2. Patients with an ASA score greater than 3
• 3. EF<40%
• 4. Those with contraindications to anesthetic drugs
• 5. Patients with BMI>30
• 6. Patients who did not want to participate in the study
• 7. Right ventricular dysfunction
• 8. COPD(Chronic obstructive pulmonary disease)
• 9. Bullous lung disease
• 10. Moderate to severe PHT
• 11. Severe kidney or liver disease
• 12. Patients with hemodynamic instability in the perioperative period
• 13. Pregnancy

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Determination of fluid responsiveness in patients undergoing coronary arter bypass surgery.	from start to 4 months	: Demonstration of fluid responsiveness in patients who will undergo coronary artery bypass surgery will prevent unnecessary fluid administration in case of hemodynamic disturbance, and medical treatments and interventions can be performed in a timely and targeted manner. Researchers will perform a recruitment maneuver on the patients and record mean arterial pressure and stroke volume index.; Researchers will perform a recruitment maneuver on the patients and record mean arterial pressure and stroke volume index.; Afterwards, researchers will give 3ml/cc balanced fluid to the patient and record the change in mean arterial pressure and stroke volume index.

Trial Locations

Locations (1)

Ankara Bilkent Şehir Hastanesi; 🇹🇷 Ankara, Turkey