Palliative Radiation for Advanced Cervical Cancer

Phase 3

• Conditions: Health Condition 1: C539- Malignant neoplasm of cervix uteri, unspecified

• Registration Number: CTRI/2019/06/019929
• Lead Sponsor: Tata memorial Centre

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Last Update Posted: 24 November 2021

Recruitment & Eligibility

• Status: Open to Recruitment
• Sex: Not specified
• Target Recruitment: 0

Inclusion Criteria

1. Locally advanced cervical cancer (Stage III B-IV A) deemed unsuitable for full course radical pelvic radiotherapy or chemoradiation due to the following reasons:

- Very large volume hard fixed disease infiltrating pelvic wall muscles and ligaments on clinical examination also classified

clinically as â??frozen pelvisâ?? wherein curative intent treatment is not envisaged or feasible.

- Fistulous communication between tumour growth and rectum and bladder >2x2 cm in size (as judged by cystoscopy for bladder infiltration or clinical or proctosigmoidoscopy examination

for rectal/sigmoid infiltration) wherein radical intent treatment is not intended or feasible and patient is not a candidate for pelvic exentration.

- Deranged renal parameters as measured by Serum Creatinine >3 mg/dl wherein diversion nephrostomy is not planned by the multidisciplinary team due to anticipated poor

clinical outcomes.Furthermore concurrence for palliative intent radiotherapy should

be corroborated by 2 staff radiation oncologists.

2. Moderate to Severe Pain on Numerical Rating Score (Score 4 or higher).

3. Anticipated survival < 12 months.

4. Patients with stage IVB with local disease extent as described in section 1 but systemic chemotherapy is not possible either due

to deranged renal function or anticipated poor tolerance.

Exclusion Criteria

1. Patients with distant metastasis needing upfront systemic therapy.

2. Presence of retroviral disease

3. Non-compliant for follow up.

4. Expected survival <3 months.

Study & Design

• Study Type: Interventional
• Study Design: Not specified