Simulation-informed Modelling and Personalized Evaluation (SIMPLE) in Ageing Populations
Not yet recruiting
- Conditions
- Neurodegenerative DiseasesAgingBrainCognitive Dysfunction
- Registration Number
- NCT06572332
- Lead Sponsor
- Chinese University of Hong Kong
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Not yet recruiting
- Sex
- All
- Target Recruitment
- 300
Inclusion Criteria
Inclusion Criteria:<br><br> - Chinese old adults are the ones who are over 60 years of chronological age.<br><br> - Sleep disturbance: individual's subjective sleep quality is assessed using the<br> Pittsburgh Sleep Quality Index (PSQI) with a total score >5.<br><br>Exclusion Criteria:<br><br> - History of bipolar disorders or psychosis.<br><br> - History of major neurological de?cits, including stroke, transient ischemic attack<br> or brain tumor.<br><br> - Unable to participant magnetic resonance imaging (MRI) scanning.
Exclusion Criteria
Not provided
Study & Design
- Study Type
- Observational
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Estimated brain age;Cognitive maintenance;Plasma ß-amyloid
- Secondary Outcome Measures
Name Time Method Brain-predicted age difference (brain-PAD);Complex attention;Memory and learning;Executive function