Venopuncture-Free Monitoring During IVF: Are More Frequent Sequential Salivary Hormone Measurements More Informative Than Daily Serum Monitoring of IVF Patients?
试验速览
- 阶段
- 不适用
- 发起方
- Boston IVF
- 入组人数
- 300
- 试验地点
- 1
- 主要终点
- Measurement of multiple Progesterone levels as an aid during an IVF cycle
研究概览
简要总结
Salivary diagnostic testing is emerging as a less invasive, inexpensive alternative to serum analyte measurements with proven diagnostic accuracy in clinical settings. This study aims to continue analyzing aspects of the performance of salivary hormone competitive immunoassays for monitoring patient's reproductive hormone profiles in the reproductive cycle. Hormone levels will be monitored during treatment cycles for infertility.
详细描述
This study will be a prospective study to measure salivary and serum estrogen and progesterone levels in subject's voluntarily undergoing monitored infertility treatment cycles including controlled ovarian stimulation (COS) with oral agents or gonadotropins and controlled ovarian hyperstimulation (COH) for in vitro fertilization (IVF). Ultimately, the potential applicability and reliability of salivary steroid monitoring in IVF cycles will be assessed.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Only
- 时间视角
- Prospective
入排标准
- 年龄范围
- 25 Years 至 43 Years（Adult）
- 性别
- Female
- 接受健康志愿者
- 是
入选标准
- •Diagnosis of infertility.
- •Cycle start age of 25 -43 years.
- •Undergoing controlled ovarian stimulation for IVF.
- •All monitoring scheduled at the participating IVF facility.
排除标准
- •Prior cancelled cycle due to hyperstimulation.
结局指标
主要结局
Measurement of multiple Progesterone levels as an aid during an IVF cycle
时间窗: 1 month
To determine if collecting multiple salivary Progesterone levels versus a single serum hormone sample could assist in predicting the administration of Human Chorionic Gonadotropin (HCG) during an IVF cycle.
次要结局
- Measurement of salivary Estradiol level as an aid during fertility treatment(1 month)
- Measurement of salivary Progesterone level as an aid during fertility treatment(1 month)