Chlorhexidine and Essential Oil Mouthwashes on Human Beta-Defensin 2 (hbD2) and Kathelicidin (LL-37) Saliva Levels

• Conditions: Periodontal Diseases; Gingivitis; Mouth and Tooth Diseases
• Interventions: Drug: undefined

• Registration Number: NCT04946617
• Lead Sponsor: Istanbul Medeniyet University

Brief Summary

Recent studies have shown that while mouthwashes exhibit antimicrobial properties against bacteria and their products, at the same time showing the cytotoxic effect on living cells in the mouth.29 To the best of our knowledge, there is no information about the toxicity effect of these two mouthwashes, which are highly preferred, on antimicrobial peptides secreted from the oral epithelium. Therefore, our aim in this study is to evaluate the effect of chlorhexidine and essential oil mouthwash on hBD2 and LL-37 in saliva.

Detailed Description

Periodontal health continues with a balanced interaction of the oral microflora with the host defense line.

Study Timeline

• Status Verified: 2021-06
• Study First Submitted: 2021-06-14
• Study First Submitted QC: 2021-06-23
• Last Update Submitted: 2021-06-23
• Study First Posted: 2021-07-01
• Last Update Posted: 2021-07-01
• Study Start: 2021-07-20
• Primary Completion: 2021-12-20
• Study Completion: 2021-12-20

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 120

Inclusion Criteria

1. systemically healthy,
2. presence of ≥20 natural teeth,
3. agreement to participate in the study .

Exclusion Criteria

1. known systemic illness,
2. smoking habit,
3. pregnancy/ lactation,
4. long-term use of anti-inflammatory drugs.

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
CP group	undefined	chronic periodontitis, ≥4 teeth in each jaw with PD of ≥5 mm, CAL of C4 mm, BOP at \[≥80 % of the proximal sites and radiographic evidence of interproximal bone loss
H group	undefined	healthy periodontium, BOP at \\20 % of the sites and no sites with probing depth (PD) \[3 mm and clinical attachment level (CAL) \[2 mm or alveolar bone loss (N = 20, 12 males, 8 females, mean age: 33.38
G group	undefined	gingivitis, BOP at ≥20 % of the sites and no sites with PD and CAL \[3 mm or bone loss (N = 20, 6 males, 14 females, mean age: 32.35);

Primary Outcome Measures

Name	Time	Method
Rate of periodontal parametres changes	6 Months	Incidence of Periodontitis