The Effect of Chlorhexidine and Essential Oil Mouthwashes on Human Beta-Defensin 2 (hbD2) and Kathelicidin (LL-37) Saliva Levels
试验速览
- 阶段
- 不适用
- 发起方
- 入组人数
- 120
- 主要终点
- Rate of periodontal parametres changes
研究概览
简要总结
Recent studies have shown that while mouthwashes exhibit antimicrobial properties against bacteria and their products, at the same time showing the cytotoxic effect on living cells in the mouth.29 To the best of our knowledge, there is no information about the toxicity effect of these two mouthwashes, which are highly preferred, on antimicrobial peptides secreted from the oral epithelium. Therefore, our aim in this study is to evaluate the effect of chlorhexidine and essential oil mouthwash on hBD2 and LL-37 in saliva.
详细描述
Periodontal health continues with a balanced interaction of the oral microflora with the host defense line.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 25 Years 至 40 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •systemically healthy,
- •presence of ≥20 natural teeth,
- •agreement to participate in the study .
排除标准
- •known systemic illness,
- •smoking habit,
- •pregnancy/ lactation,
- •long-term use of anti-inflammatory drugs.
研究组 & 干预措施
H group
healthy periodontium, BOP at \20 % of the sites and no sites with probing depth (PD) [3 mm and clinical attachment level (CAL) [2 mm or alveolar bone loss (N = 20, 12 males, 8 females, mean age: 33.38
干预措施: undefined (Drug)
G group
gingivitis, BOP at ≥20 % of the sites and no sites with PD and CAL [3 mm or bone loss (N = 20, 6 males, 14 females, mean age: 32.35);
干预措施: undefined (Drug)
CP group
chronic periodontitis, ≥4 teeth in each jaw with PD of ≥5 mm, CAL of C4 mm, BOP at [≥80 % of the proximal sites and radiographic evidence of interproximal bone loss
干预措施: undefined (Drug)
结局指标
主要结局
Rate of periodontal parametres changes
时间窗: 6 Months
Incidence of Periodontitis
次要结局
未报告次要终点
研究者
Mustafa Cihan Yavuz
Assistant Professor
Istanbul Medeniyet University