Proportion of patients who are unable to get liberated from artificial breathing machine and their characteristics.

Not yet recruiting

Conditions: Certain infectious and parasitic diseases, (2) ICD-10 Condition: I00-I99||Diseases of the circulatory system, (3) ICD-10 Condition: G00-G99||Diseases of the nervous system, (4) ICD-10 Condition: J00-J99||Diseases of the respiratory system,

Brief Summary: mechanical ventilation is a common treatment for critically ill children admitted to pediatric intensive care unit. extubation failure is associated with increased morbidity and mortality. extubation failure rate across world various studys is from 2.7-22%. several indices and biomarkers including BNP were studied for association with failed extubation. there are no indian studies in pediatric intensive care unit to validate risk factors to extubation failure. our research question is - what is the incidence of extubation failure in children undergoing mechanical ventilation. and what are the predictors of extubation failure in children undergoing mechanical ventilation.

all children undergoing mechanical ventilation who are meeting inclusion criteria will be included instudy after obtaining appropriate informed consent. details of demography, clinical, and mechanical ventilation paramteres wil be recorded. decision to extubation will be taken by treating team of PICI. before extubation all children will undergo Spontaneous breath trial as per PICU protocol . 1st BNP sample will be taken when decision extubation (and sedation stopped), and 2nd BNP at end of SBT. children who tolerated and passed SBT will be extubated. extubation failure will be defined as requirement of reintubation due to any reason with in 48 hours of extubation. data will be analysed as per appropriate statistical test, .

Recruitment & Eligibility

Inclusion Criteria

all children admitted in PICU on mechanical ventilation.

Exclusion Criteria

1.Children who had accidental extubation.
2.Children who expire during their PICU stay 3.Children who have undergone tracheostomy after few days of intubation.

Primary Outcome Measures

Name	Time	Method
extubation failure	with in 48 hours of extubation

Secondary Outcome Measures

Name	Time	Method
To identify risk factors associated with extubation failure.	a.Clinical parameters: age, diagnosis, comorbidities

Locations (1): JIPMER
🇮🇳
Pondicherry, PONDICHERRY, India
JIPMER
🇮🇳Pondicherry, PONDICHERRY, India
Dr Lolam Venkatesh
Principal investigator
8727003332
lolamvenkatesh502@gmail.com